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      Recent progress in the design fabrication of metal-organic frameworks-based nanozymes and their applications to sensing and cancer therapy

      , , , , , , ,
      Biosensors and Bioelectronics
      Elsevier BV

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          Abstract

          The nanomaterials with enzyme-like catalytic activity, named as nanozymes, have aroused wide research interest owing to their striking merits. Metal-organic frameworks (MOFs) have showed great prospect in the construction of novel nanozymes. In this review, firstly, we summarize the most recent contributions in the design construction of the MOFs-based nanozymes. Then, we concentrate our attention on their applications in the fields of sensing and cancer therapies. According to the design strategies, we categorized MOFs-based nanozymes into four classes for review (i.e. pristine MOFs, MOFs with modification, MOFs-based nanocomposites, and MOF derivatives). Meanwhile, the emerging and fascinating 2D MOFs-based nanozymes were also reviewed. A variety of novel applications are also discussed, including nanozymes catalytic mediated signal amplification in sensing applications (e.g. colorimetric sensing, fluorescent sensing, chemiluminescent sensing, electrochemical sensing, and surface-enhanced Raman scattering (SERS)), and nanozymes catalytic mediated cancer therapy (i.e. cancer-starvation therapy, enhancing photodynamic therapy, and cancer-starvation and PDT synergistic therapy). At the end of the article, future opportunities and challenges in this promising research area are tentatively proposed.

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          Author and article information

          Journal
          Biosensors and Bioelectronics
          Biosensors and Bioelectronics
          Elsevier BV
          09565663
          May 2019
          May 2019
          Article
          10.1016/j.bios.2019.04.061
          31100598
          b76ea32b-adcd-4b11-9eec-963039912882
          © 2019

          https://www.elsevier.com/tdm/userlicense/1.0/

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