Quantification of human and rodent brown adipose tissue function using 99mTc-methoxyisobutylisonitrile SPECT/CT and 18F-FDG PET/CT.

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Abstract

For brown adipose tissue (BAT) to be effective at consuming calories, its blood flow must increase enough to provide sufficient fuel to sustain energy expenditure and also transfer the heat created to avoid thermal injury. Here we used a combination of human and rodent models to assess changes in BAT blood flow and glucose utilization.

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Journal

Journal ID (iso-abbrev): J. Nucl. Med.

Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Publisher: Society of Nuclear Medicine

ISSN (Electronic): 1535-5667

ISSN (Print): 0161-5505

Publication date (Electronic): Nov 2013

Volume: 54

Issue: 11

Affiliations

[1 ] Section of Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.

Article

Publisher Item ID: jnumed.113.121012 Mid ID: NIHMS575428

DOI: 10.2967/jnumed.113.121012

PMC ID: 4012367

PubMed ID: 24071505

SO-VID: b791885c-c8cd-441f-b9f9-36eee2d3e82a

History

Keywords: blood flow,brown fat,glucose uptake

Data availability:

Keywords: blood flow, brown fat, glucose uptake

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