Repeated Administration of Duloxetine Suppresses Neuropathic Pain by Accumulating Effects of Noradrenaline in the Spinal Cord.

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Abstract

Antidepressants are used to treat neuropathic pain and although the detailed mechanisms of their effects are unclear, the descending noradrenergic inhibitory system might play an important role. We tested our hypothesis that repeated administration of duloxetine suppresses neuropathic pain by restoring the descending noradrenergic inhibitory system in rats 6 weeks after spinal nerve ligation (SNL).

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Journal

Journal ID (iso-abbrev): Anesth. Analg.

Title: Anesthesia and analgesia

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1526-7598

ISSN (Print): 0003-2999

Publication date (Electronic): Aug 04 2017

Affiliations

[1 ] From the *Department of Anesthesiology, Gunma University Graduate School of Medicine, Gunma, Japan; and †Center for Pain Management, Department of Anesthesiology, Fukushima Medical University Hospital, Fukushima Medical University, Fukushima, Japan.

Article

DOI: 10.1213/ANE.0000000000002380

PubMed ID: 28787337

SO-VID: b799f045-ffb1-4561-8fb0-014306a7df67

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