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      Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells.

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          Abstract

          Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and humans. In recent years, new mouse models have led to the identification of other langerin(+) DC subsets that are not present in the epidermis, including a subset of DCs that is found in most non-lymphoid tissues. In this Review we describe new developments in the understanding of the biology of LCs and other langerin(+) DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity.

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          Author and article information

          Journal
          Nat Rev Immunol
          Nature reviews. Immunology
          Springer Science and Business Media LLC
          1474-1741
          1474-1733
          Dec 2008
          : 8
          : 12
          Affiliations
          [1 ] Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA. Miriam.Merad@mssm.edu
          Article
          nri2455
          10.1038/nri2455
          19029989
          b79c18bc-7d9b-45ea-ac11-78a23ef1f450
          History

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