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      Humulon, a bitter in the hop, inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.

      1 , ,

      Oncology

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          Abstract

          Humulon, one of the bitters in the hop, was isolated from the female flowers of Humulus lupulus. This component has inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation. At 1 mg/mouse, humulon inhibited markedly the tumor-promoting effect of TPA (1 microgram/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[a]anthracene (50 micrograms/mouse). Furthermore, humulon inhibited arachidonic acid-induced inflammatory ear edema in mice.

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          Author and article information

          Affiliations
          [1 ] College of Pharmacy, Nihon University, Chiba, Japan.
          Journal
          Oncology
          Oncology
          0030-2414
          0030-2414
          : 52
          : 2
          7854777

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