Numerous Brugada syndrome-associated genetic variants have no effect on J-point elevation, syncope susceptibility, malignant cardiac arrhythmia, and all-cause mortality.

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Abstract

We investigated whether Brugada syndrome (BrS)-associated variants identified in the general population have an effect on J-point elevation as well as whether carriers of BrS variants were more prone to experience syncope and malignant ventricular arrhythmia and had increased mortality compared with noncarriers.

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Journal

Journal ID (iso-abbrev): Genet. Med.

Title: Genetics in medicine : official journal of the American College of Medical Genetics

Publisher: Springer Nature

ISSN (Electronic): 1530-0366

ISSN (Print): 1098-3600

Publication date (Electronic): May 2017

Volume: 19

Issue: 5

Affiliations

[1 ] The Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark.

[2 ] Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre, University Hospital of Copenhagen, Rigshospitalet, Denmark.

[3 ] The Novo Nordisk Foundation Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.

[4 ] Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.

[5 ] Research Centre for Prevention and Health, The Capital Region, Copenhagen, Denmark.

[6 ] Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark.

[7 ] Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

[8 ] Laboratory of Experimental Cardiology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

Article

Publisher Item ID: gim2016151

DOI: 10.1038/gim.2016.151

PubMed ID: 27711072

SO-VID: b79ef33f-6501-4949-95ea-f0bb4697d3da

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