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      Tissue engineering of urinary organs.

      1 , ,

      Yonsei medical journal

      Yonsei University College of Medicine (KAMJE)

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          Abstract

          Tissue engineering can serve as an alternative treatment for a malfunctioning or lost organ. Isolated and expanded cells adhere to a temporary scaffold, proliferate, and secrete their own extracellular matrices (ECM) replacing the biodegrading scaffold. The genitourinary system, composed of the kidney, ureter, bladder, urethra, and genital organs, is exposed to a variety of possible injury sites from the time of fetal development. All the urinary organs are mainly composed of smooth muscle and uroepithelial cells and which may be approached by tissue engineering techniques. A large number of materials, including naturally-derived and synthetic polymers have been utilized to fabricate prostheses for the genitourinary system. Usually, whenever there is a lack of native urologic tissue, reconstruction is considered with native non-urologic tissue, such as, gastrointestinal segments, or skin or mucosa from multiple body sites. Engineering tissues using selective cell transplantation may provide a means to create functional new genitourinary tissues. This review concerns urinary tissues reconstructed with bladder uroepithelial cells and smooth muscle cells (SMCs) implanted on biodegradable polymer matrices.

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          Author and article information

          Affiliations
          [1 ] Department of Molecular Science and Technology, Ajou University, Suwon, Korea. kdp@madang.ajou.ac.kr
          Journal
          Yonsei Med. J.
          Yonsei medical journal
          Yonsei University College of Medicine (KAMJE)
          0513-5796
          0513-5796
          Dec 2000
          : 41
          : 6
          10.3349/ymj.2000.41.6.780
          11204829

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