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Effect of alpha1-adrenoceptor antagonist exposure on prostate cancer incidence: an observational cohort study.
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Abstract
The quinazoline based alpha1-adrenoceptor antagonists doxazosin and terazosin suppress prostate tumor growth via the induction of apoptosis and decrease in tissue vascularity. To assess the effect of alpha1-blocker exposure on the incidence of prostate cancer we performed an exploratory, observational cohort study.