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      An update on memory reconsolidation updating

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          Abstract

          The reactivation of a synaptically stored memory in the brain can make the memory transiently labile. During the time it takes for the memory to re-stabilize (reconsolidate), the memory can either be reduced by an amnesic agent or enhanced by memory enhancers. The change in memory expression is related to changes in the brain correlates of long-term memory. Many have suggested that such retrieval-induced plasticity is ideally placed to enable memories to be updated with new information. This hypothesis has been tested experimentally, with a translational perspective, by attempts to update maladaptive memories in order to reduce their problematic impact. Here, we review the progress on reconsolidation-update studies, highlighting their translational exploitation and addressing recent challenges to the reconsolidation field.

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          Author and article information

          Journal
          9708669
          21214
          Trends Cogn Sci
          Trends Cogn. Sci. (Regul. Ed.)
          Trends in cognitive sciences
          1364-6613
          1879-307X
          5 May 2017
          08 May 2017
          July 2017
          01 July 2018
          : 21
          : 7
          : 531-545
          Affiliations
          [1 ]University of Birmingham, School of Psychology
          [2 ]McGill University, Department of Psychology
          [3 ]Icahn School of Medicine at Mount Sinai, Psychiatry and Neuroscience Departments, and Friedman Brain Institute
          Author notes
          Article
          PMC5605913 PMC5605913 5605913 nihpa870612
          10.1016/j.tics.2017.04.006
          5605913
          28495311
          Categories
          Article

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