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      Effects of acetyl-strophanthidin on left ventricular function and ventricular arrhythmias.

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      American heart journal
      Elsevier BV

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          Abstract

          Digitalis drugs can suppress ventricular arrhythmias. It is uncertain whether this effect results from improved left ventricular (LV) function. We utilized radionuclide scanning techniques to evaluate changes in LV ejection fraction (EF) after an infusion of acetyl-strophanthidin in 43 patients with frequent ventricular premature beats (VPBs) (44 to 2400/hr). Acetyl-strophanthidin suppressed ventricular arrhythmia in 17 patients, but LVEF increased in only six of these patients (57% to 67%), while it was unaltered in 11 patients (28% to 30%). In 26 patients ventricular arrhythmia was not suppressed. Fifteen of these patients had an increase in LVEF (60% vs 71%), while this was unchanged in 11 patients (27% vs 29%). Thus no correlation was observed between the positive inotropic and antiarrhythmic action of acetyl-strophanthidin on ventricular arrhythmia and LVEF. We conclude that the suppression of VPBs by acetyl-strophanthidin is independent of the drug's effects on LV function. Evidence is reviewed suggesting that the antiarrhythmic effect of acetyl-strophanthidin on ventricular ectopic activity is due to its vagotonic action.

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          Author and article information

          Journal
          Am Heart J
          American heart journal
          Elsevier BV
          0002-8703
          0002-8703
          May 1984
          : 107
          : 5 Pt 1
          Article
          0002-8703(84)90822-6
          10.1016/0002-8703(84)90822-6
          6720517
          b7b7b62d-94b9-43e2-a434-36dc0d9c97b6
          History

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