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      18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease-Brief Report.

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          Abstract

          This study sought to determine whether 18F-fluorodeoxyglucose-positron emission tomography/computed tomography could be applied to a murine model of advanced atherosclerotic plaque vulnerability to detect response to therapeutic intervention and changes in lesion stability. Approach and Results: To analyze plaques susceptible to rupture, we fed ApoE-/- mice a high-fat diet and induced vulnerable lesions by cast placement over the carotid artery. After 9 weeks of treatment with orthogonal therapeutic agents (including lipid-lowering and proefferocytic therapies), we assessed vascular inflammation and several features of plaque vulnerability by 18F-fluorodeoxyglucose-positron emission tomography/computed tomography and histopathology, respectively. We observed that 18F-fluorodeoxyglucose-positron emission tomography/computed tomography had the capacity to resolve histopathologically proven changes in plaque stability after treatment. Moreover, mean target-to-background ratios correlated with multiple characteristics of lesion instability, including the corrected vulnerability index.

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          Author and article information

          Journal
          Arterioscler Thromb Vasc Biol
          Arteriosclerosis, thrombosis, and vascular biology
          Ovid Technologies (Wolters Kluwer Health)
          1524-4636
          1079-5642
          December 2020
          : 40
          : 12
          Affiliations
          [1 ] Division of Vascular Surgery, Department of Surgery (K.-U.J., J.Y., Y.K., V.N., A.M.F., P.T., Y.W., A.V.E., M.L., M.K., N.J.L.), Stanford University School of Medicine, CA.
          [2 ] Department of Pathology, The University of Alabama at Birmingham (V.N.).
          [3 ] Department for Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany (P.T., L.M.).
          [4 ] Department of Radiology (N.H.-N.), Stanford University School of Medicine, CA.
          [5 ] Department of Biomedical Engineering, Michigan State University, East Lansing (B.R.S.).
          [6 ] Institute for Quantitative Health Science and Engineering, East Lansing, MI (B.R.S.).
          [7 ] German Center for Cardiovascular Research (DZHK partner site Munich), Germany (L.M.).
          [8 ] Division of Cardiovascular Medicine, Department of Medicine (N.J.L.), Stanford University School of Medicine, CA.
          [9 ] Stanford Cardiovascular Institute, Stanford University, CA (N.J.L.).
          Article
          NIHMS1637328
          10.1161/ATVBAHA.120.315239
          7686289
          33086865
          b7bd0c4d-62ab-4d5f-a442-f34b5b26e7a9
          History

          atherosclerosis,inflammation,mice,plaque, atherosclerotic,stroke

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