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      Fluorine in medicinal chemistry.

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      Publication date:
      Journal: Chemical Society Reviews
      Publisher: Royal Society of Chemistry (RSC)

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          Abstract

          It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.

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          PubMed ID:: 18197348
          DOI:: 10.1039/b610213c

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