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      Green synthesis of Zingiberis rhizoma-based carbon dots attenuates chemical and thermal stimulus pain in mice

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          Abstract

          Aim: To evaluate the analgesic activity of Zingiberis rhizoma-based carbon dots (ZR-CDs). Materials & methods: Novel ZR-CDs were prepared via a facile, green pyrolysis method. Microstructure, optical and functional group properties were characterized. Acetic acid writhing, hot-plate and tail-immersion tests were performed using mice to evaluate the analgesic activity of ZR-CDs, followed by a preliminary study on the analgesic mechanism. Results: ZR-CDs with a quantum yield of 5.2% had a diameter ranging from 2.23 to 3.77 nm. Remarkable analgesic effect of ZR-CDs was observed against both thermal and chemical stimulus tests, possibly mediated by an opioid-like mechanism and the regulation of 5-hydroxytryptamine levels. Conclusion: ZR-CDs have a promising potential for biomedical application in relieving pain-related diseases.

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          Author and article information

          Journal
          Nanomedicine
          Nanomedicine
          Future Medicine Ltd
          1743-5889
          1748-6963
          April 2020
          April 2020
          : 15
          : 9
          : 851-869
          Affiliations
          [1 ]School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, PR China
          [2 ]School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, PR China
          [3 ]Center of Scientific Experiment, Beijing University of Chinese Medicine, Beijing, 100029, PR China
          Article
          10.2217/nnm-2019-0369
          32238028
          b7d08e8e-c237-4cac-9376-dd67ec88f2a2
          © 2020
          History

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