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      Failure of Oral 5-Hydroxytryptophan Administration to Affect Prolactin Secretion in Man

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          Oral 5-hydroxytryptophan (5-HTP) administration, either 200 mg acutely or 50 mg q.i.d. for 3 days plus 200 mg acutely, failed to modify either basal or TRH-stimulated prolactin secretion in normal subjects. This is at variance with the stimulatory action of intravenous tryptophan on human prolactin release. However, it is doubtful that 5-HTP at the dose used may increase brain serotonin concentration; moreover, the hydroxylated amino acid is also taken up by catecholaminergic neurons, from which noradrenaline and dopamine may then be released. It is concluded that the failure of 5-HTP to affect prolactin secretion in man is not a proof against the existence of serotoninergic stimulatory influences on human prolactin release.

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          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 7
          : 4-5
          : 303-307
          Second Medical Clinic, Endocrine Unit, University of Milan, Milan
          178741 Horm Res 1976;7:303–307
          © 1976 S. Karger AG, Basel

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          Pages: 5
          Short Communication


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