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      Influence of ultrafiltration membrane on ophiopogonins and homoisoflavonoids in Ophiopogon japonicus as measured by ultra-fast liquid chromatography coupled with ion trap time-of-flight mass spectrometry

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          Ultrafiltration is one of the most fascinating technologies, which makes it possible to improve the quality of traditional medicines for application in the pharmaceutical industry. However, researchers have paid little attention to the effect of ultrafiltration membrane on traditional medicines chemical constituents. In this work, Ophiopogon japonicus (L.f) Ker-Gawl. was used as an example to illuminate the influence of ultrafiltration with different material and molecular weight cut-off (MWCO) membrane on natural chemical constituents as measured by ultra-fast liquid chromatography coupled with ion trap time-of-flight mass spectrometry (UFLC-IT-TOF/MS). Our results indicated that ultrafiltration membrane significantly impacted homoisoflavonoids, especially homoisoflavonoids that were almost completely retained on the polyethersulfone (PES) membrane. We also found that the larger number of aglycone hydroxy and sugar moiety in steroid saponins, the higher the transmittance. Furthermore, the passage rate (%) of ophiogenin type saponins was higher than that of others. The possible adsorptive mechanisms were hydrogen bonding, hydrophobic interactions, and benzene ring interaction by π-π stacking. In conclusion, it is crucial to choose appropriate ultrafiltration membrane based on the characteristics of produce products for application of ultrafiltration technique.

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          Most cited references 26

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          Membrane fouling control in ultrafiltration technology for drinking water production: A review

           Heng Liang,  Jun Ma,  Mei Han (2011)
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            Fouling and cleaning of ultrafiltration membranes: A review

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              Improving the antifouling property of polysulfone ultrafiltration membrane by incorporation of isocyanate-treated graphene oxide.

              In this paper, isocyanate-treated graphene oxide (iGO), which can be well dispersed in organic solvent, was prepared in a simple manner and showed excellent compatibility with polysulfone (PSF). iGO-PSF ultrafiltration membranes were prepared by the classical phase inversion method. The separation performance and the antifouling property of the prepared membranes were investigated in detail. The antifouling property of the prepared membranes was found to be greatly enhanced by the addition of iGO, and we attributed the enhanced antifouling property to the improved hydrophilicity, the more negative zeta potential and the improved smoothness of the membrane surface.

                Author and article information

                Chinese Journal of Natural Medicines
                20 February 2017
                : 15
                : 2
                : 121-141
                1Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198, China
                2Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin, 300410, China
                3State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
                4Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang 550004, China
                Author notes
                *Corresponding author: YU Bo-Yang, Tel: 86-25-86185157, Fax: 86-25-86185158; E-mail: boyangyu59@ 123456163.com ; JU Ai-Chun, juach@ 123456tasly.com

                These authors have no conflict of interest to declare.

                Copyright © 2017 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
                Funded by: National Natural Science Foundation of China
                Award ID: 81473317
                Award ID: 81274004
                This work was supported by the National Natural Science Foundation of China (Nos. 81473317, 81274004), 2011 Program for Excellent Scientific and Technological Innovation Team of Jiangsu Higher Education, a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.


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