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      Rhodium-catalyzed asymmetric hydrogenation using self-assembled chiral bidentate ligands

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          Abstract

          The chirality-directed self-assembly of bifunctional subunits around a structural metal - typically, zinc(II) - is used to form a heteroleptic complex in which a second set of ligating groups are suitably disposed to bind a second metal, forming a heterobimetallic catalyst system. We find that subtle changes in the structural backbone (i.e., ligand scaffold) of such chiral bidentate self-assembled ligands (SALs) can be used to manipulate the ligand topography and chiral environment around catalytic metal; thus, the scaffold can be optimized to maximize asymmetric induction. Using this combinatorial strategy for ligand synthesis, a preliminary study was carried out in which a library of 110 SALs was evaluated in the rhodium-catalyzed asymmetric hydrogenation of a simple

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          Author and article information

          Journal
          Pure and Applied Chemistry
          International Union of Pure and Applied Chemistry (IUPAC)
          1365-3075
          0033-4545
          January 1 2006
          January 1 2006
          : 78
          : 2
          : 501-509
          Article
          10.1351/pac200678020501
          b7f531dc-65da-406d-9b89-eee860940872
          © 2006
          History

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