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Chronic [d-Ala2, d-Leu5]enkephalin treatment increases the nerve growth factor in adult mouse brain
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Abstract
The delta opioid peptide [D-Ala(2), D-Leu(5)]enkephalin (DADLE) has been shown to
enhance the survival of dopaminergic neurons. Here, we found that chronic treatment
with DADLE caused a significant increase in nerve growth factor (NGF) in the hippocampus
and the midbrain of adult albino Swiss (CD-1) mice, but not in the striatum or frontal
cortex. Glia-derived neurotrophic factor (GDNF) was not significantly affected. Thus,
the neuroprotective action of DADLE may be mediated in part by NGF.