Derivation of a multivariate reference range for pituitary thyrotropin and thyroid hormones: diagnostic efficiency compared with conventional single-reference method.

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Abstract

: Although pituitary thyrotropin (TSH) and thyroid hormones are physiologically interrelated, interpretation of measurements is conventionally done separately. Classification of subclinical thyroid dysfunction depends by definition solely on an abnormal TSH. This study examines a composite multivariate approach to disease classification.

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Journal

Journal ID (iso-abbrev): Eur. J. Endocrinol.

Title: European journal of endocrinology / European Federation of Endocrine Societies

ISSN (Electronic): 1479-683X

ISSN (Print): 0804-4643

Publication date (Electronic): Jun 2016

Volume: 174

Issue: 6

Affiliations

[1 ] Department for Nuclear MedicineKlinikum Lüdenscheid, Lüdenscheid, Germany rudolf.hoermann@gmail.com.

[2 ] Department for Nuclear MedicineKlinikum Lüdenscheid, Lüdenscheid, Germany.

[3 ] Medical Department IEndocrinology and Diabetology, Bergmannsheil University Hospitals, Ruhr University of Bochum, Bochum, Germany Ruhr Center for Rare Diseases (CeSER)Ruhr University of Bochum and Witten/Herdecke University, Bochum, Germany.

[4 ] North Lakes ClinicalIlkley, UK.

Article

Publisher Item ID: EJE-16-0031

DOI: 10.1530/EJE-16-0031

PubMed ID: 26951601

SO-VID: b82701b9-e936-4358-9dc6-2e57155cd6c6

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