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      Enzymic Activity in Rat Uterus during Early Pregnancy


      Hormone Research in Paediatrics

      S. Karger AG

      Uterus, Pregnancy, Enzyme activity, Phosphatases, Nucleotide synthesis

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          Total protein, RNA and DNA content and the activity of acid and alkaline phosphatases, 5´-nucleotidase and isocitrate dehydrogenase were studied in rat uterus during the first 8 days of pregnancy. Isocitrate dehydrogenase activity showed marked fluctuations from day to day. Nucleotidase and acid phosphatase activities showed a significant increase on day 8. The most marked change in activity was that of alkaline phosphatase which showed a 10-fold increase between days 6 and 8, due largely to an increase in the activity of this enzyme in the decidual nodule. The rise in alkaline phosphatase activity did not occur in rats ovariectomized on days 1, 2 or 4 of pregnancy and was markedly decreased in those ovariectomized on day 6. [<sup>3</sup>H]-uridine incorporation into RNA showed a significant increase between days 2 and 6 whereas [<sup>3</sup>H]-thymidine incorporation into DNA showed a significant increase on day 6.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          21 November 2008
          : 6
          : 2
          : 95-104
          Royal Postgraduate Medical School, London
          178667 Horm Res 1975;6:95–104
          © 1975 S. Karger AG, Basel

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          Page count
          Pages: 10


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