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      The expanding scope of antimicrobial peptide structures and their modes of action.

      1 , ,

      Trends in biotechnology

      Elsevier BV

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          Abstract

          Antimicrobial peptides (AMPs) are an integral part of the innate immune system that protect a host from invading pathogenic bacteria. To help overcome the problem of antimicrobial resistance, cationic AMPs are currently being considered as potential alternatives for antibiotics. Although extremely variable in length, amino acid composition and secondary structure, all peptides can adopt a distinct membrane-bound amphipathic conformation. Recent studies demonstrate that they achieve their antimicrobial activity by disrupting various key cellular processes. Some peptides can even use multiple mechanisms. Moreover, several intact proteins or protein fragments are now being shown to have inherent antimicrobial activity. A better understanding of the structure-activity relationships of AMPs is required to facilitate the rational design of novel antimicrobial agents.

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          Author and article information

          Journal
          Trends Biotechnol
          Trends in biotechnology
          Elsevier BV
          1879-3096
          0167-7799
          Sep 2011
          : 29
          : 9
          Affiliations
          [1 ] Biochemistry Research Group, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada, T2N 1N4.
          Article
          S0167-7799(11)00088-6
          10.1016/j.tibtech.2011.05.001
          21680034
          e8d3dc10-a96d-41df-8f01-552ae613b898
          Copyright © 2011 Elsevier Ltd. All rights reserved.

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