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      Glucose-6-Phosphate Content in Mammalian Pancreatic β-Cells

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          Glucose-6-phosphate was measured in microdissected pancreatic islets obtained from obese-hyperglycemic mice. Exposure of the islets in a low glucose medium to the hypoglycemic sulfonylurea compound glibenclamide resulted in a significant decrease of glucose-6-phosphate. This effect might be due to uncoupling of the oxidative phosphorylation leading to an accelerated glycolytic rate. Under the same experimental conditions another stimulator of insulin release, dibutyryl cyclic 3,5-AMP, induced a slight increase in glucose-6-phosphate. Inhibition of the glucose-induced insulin release by epinephrine, diazoxide or omission of Ca<sup>+ +</sup> resulted in considerably elevated islet levels of glucose-6-phosphate. A reduced availability of Ca<sup>+ +</sup> may be a common denominator forthis effect on glucose-6-phosphate.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          21 November 2008
          : 2
          : 6
          : 371-377
          Department of Histology, University of Umeå, Umeå
          178249 Hormones 1971;2:371–377
          © 1971 S. Karger AG, Basel

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          Pages: 7


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