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      Morphological Study on the Human Developing Vitreous Collagen Fibrils and Persistent Hyperplastic Primary Vitreous


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          The human primary vitreous fibrils were similar to the secondary vitreous fibrils on electron microscopic observation. On the other hand, the intravitreal strand in a persistent hyperplastic primary vitreous (PHPV) contained large numbers of collagenous fibrils with 40–50 nm diameters and about 65 nm cross-striation periodicity. Besides these, other types of noncross-striated fibrils, ranging in diameter from 10 to 30 nm were observed in the circumferential region of the intravitreal strand. Moreover, there was complete morphological continuation between the intravitreal strand and the optic disc. Their histo-chemical properties were very likely collagenous and in part glial. Although the results are based only on 1 case of PHPV, present observations showed that components of the intravitreal strand of PHPV considerably differed from the primary vitreous.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          04 December 2009
          : 17
          : 1
          : 60-64
          Department of Ophthalmology, School of Medicine, Keio University, Tokyo, Japan
          265351 Ophthalmic Res 1985;17:60–64
          © 1985 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 20 June 1983
          : 19 March 1984
          Page count
          Pages: 5
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Human primary vitreous,Persistent hyperplastic primary vitreous (PHPV)


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