For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
21
views
169
references
 Top references
cited by
99
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      329
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Magnesium and Human Health: Perspectives and Research Directions

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Magnesium is the fourth most abundant cation in the body. It has several functions in the human body including its role as a cofactor for more than 300 enzymatic reactions. Several studies have shown that hypomagnesemia is a common electrolyte derangement in clinical setting especially in patients admitted to intensive care unit where it has been found to be associated with increase mortality and hospital stay. Hypomagnesemia can be caused by a wide range of inherited and acquired diseases. It can also be a side effect of several medications. Many studies have reported that reduced levels of magnesium are associated with a wide range of chronic diseases. Magnesium can play important therapeutic and preventive role in several conditions such as diabetes, osteoporosis, bronchial asthma, preeclampsia, migraine, and cardiovascular diseases. This review is aimed at comprehensively collating the current available published evidence and clinical correlates of magnesium disorders.

          Related collections

          Most cited references169

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          Editorial

          Robert Aune, Matthew Taliaferro, Adam Sage … (2000)
          Article 0 comments Cited 1601 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

            Mark L. Mayer, Gary L. Westbrook, Peter Guthrie (1984)
            Article 0 comments Cited 177 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              TRPM7 Provides an Ion Channel Mechanism for Cellular Entry of Trace Metal Ions

              Mahealani K. Monteilh-Zoller, Meredith C. Hermosura, Monica Nadler … (2003)
              Trace metal ions such as Zn2+, Fe2+, Cu2+, Mn2+, and Co2+ are required cofactors for many essential cellular enzymes, yet little is known about the mechanisms through which they enter into cells. We have shown previously that the widely expressed ion channel TRPM7 (LTRPC7, ChaK1, TRP-PLIK) functions as a Ca2+- and Mg2+-permeable cation channel, whose activity is regulated by intracellular Mg2+ and Mg2+·ATP and have designated native TRPM7-mediated currents as magnesium-nucleotide–regulated metal ion currents (MagNuM). Here we report that heterologously overexpressed TRPM7 in HEK-293 cells conducts a range of essential and toxic divalent metal ions with strong preference for Zn2+ and Ni2+, which both permeate TRPM7 up to four times better than Ca2+. Similarly, native MagNuM currents are also able to support Zn2+ entry. Furthermore, TRPM7 allows other essential metals such as Mn2+ and Co2+ to permeate, and permits significant entry of nonphysiologic or toxic metals such as Cd2+, Ba2+, and Sr2+. Equimolar replacement studies substituting 10 mM Ca2+ with the respective divalent ions reveal a unique permeation profile for TRPM7 with a permeability sequence of Zn2+ ≈ Ni2+ >> Ba2+ > Co2+ > Mg2+ ≥ Mn2+ ≥ Sr2+ ≥ Cd2+ ≥ Ca2+, while trivalent ions such as La3+ and Gd3+ are not measurably permeable. With the exception of Mg2+, which exerts strong negative feedback from the intracellular side of the pore, this sequence is faithfully maintained when isotonic solutions of these divalent cations are used. Fura-2 quenching experiments with Mn2+, Co2+, or Ni2+ suggest that these can be transported by TRPM7 in the presence of physiological levels of Ca2+ and Mg2+, suggesting that TRPM7 represents a novel ion-channel mechanism for cellular metal ion entry into vertebrate cells.
              Article 0 comments Cited 136 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Abdullah M. Al Alawi:
                ORCID: http://orcid.org/0000-0003-2077-7186
                Journal
                Journal ID (nlm-ta): Int J Endocrinol
                Journal ID (iso-abbrev): Int J Endocrinol
                Journal ID (publisher-id): IJE
                Title: International Journal of Endocrinology
                Publisher: Hindawi
                ISSN (Print): 1687-8337
                ISSN (Electronic): 1687-8345
                Publication date Collection: 2018
                Publication date (Electronic): 16 April 2018
                Volume: 2018
                Electronic Location Identifier: 9041694
                Affiliations
                1Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia
                2Department of Medicine, Sultan Qaboos University Hospital, Muscat, Oman
                3Menzies School of Health Research, Darwin, NT, Australia
                4Northern Territory Medical Program, Flinders University School of Medicine, Darwin, NT, Australia
                5Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden
                6Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
                Author notes

                Academic Editor: Michael Horowitz

                Author information
                http://orcid.org/0000-0003-2077-7186
                http://orcid.org/0000-0002-5622-6987
                Article
                DOI: 10.1155/2018/9041694
                PMC ID: 5926493
                PubMed ID: 29849626
                SO-VID: b856eec4-77a1-47f1-84c2-d8074e594912
                Copyright © Copyright © 2018 Abdullah M. Al Alawi et al.
                License:

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 12 October 2017
                Date revision received : 22 February 2018
                Date accepted : 5 March 2018
                Categories
                Subject: Review Article

                ScienceOpen disciplines: Endocrinology & Diabetes
                Data availability:
                ScienceOpen disciplines: Endocrinology & Diabetes

                Comments

                Comment on this article

                scite_

                Similar content329

                See all similar

                Cited by95

                See all cited by

                Most referenced authors1,713

                See all reference authors