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      Anti-Inflammatory Activity of Alkaloids: An Update from 2000 to 2010

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          Abstract

          Many natural substances with proven anti-inflammatory activity have been isolated throughout the years. The aim of this review is to review naturally sourced alkaloids with anti-inflammatory effects reported from 2000 to 2010. The assays were conducted mostly in vivo, and carrageenan-induced pedal edema was the most used experimental model. Of the 49 alkaloids evaluated, 40 demonstrated anti-inflammatory activity. Of these the most studied type were the isoquinolines. This review was based on NAPRALERT data bank, Web of Science and Chemical Abstracts. In this review, 95 references are cited.

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          A review of natural products with antileishmanial activity.

          Arménio Barbosa, O Macedo, Charles D S Almeida … (2005)
          Infections caused by protozoa of the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries. The incidence of the disease has increased since the emergence of AIDS. In the absence of a vaccine, there is an urgent need for effective drugs to replace/supplement those in current use. The plant kingdom is undoubtedly valuable as a source of new medicinal agents. The present work constitutes a review of the literature on plant extracts and chemically defined molecules of natural origin showing antileishmanial activity. The review refers to 101 plants, their families, and geographical distribution, the parts utilized, the type of extract and the organism tested. It also includes 288 compounds isolated from higher plants and microorganisms, classified into appropriate chemical groups. Some aspects of recent antileishmanial-activity-directed research on natural products are discussed.
          Article 0 comments Cited 110 times – based on 0 reviews     Review now
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            Flavonoids with Gastroprotective Activity

            Kelly de Lira Mota, Guilherme Dias, Meri Emili Ferreira Pinto … (2009)
            Peptic ulcers are a common disorder of the entire gastrointestinal tract that occurs mainly in the stomach and the proximal duodenum. This disease is multifactorial and its treatment faces great difficulties due to the limited effectiveness and severe side effects of the currently available drugs. The use of natural products for the prevention and treatment of different pathologies is continuously expanding throughout the world. This is particularly true with regards to flavonoids, which represent a highly diverse class of secondary metabolites with potentially beneficial human health effects that is widely distributed in the plant kingdom and currently consumed in large amounts in the diet. They display several pharmacological properties in the gastroprotective area, acting as anti-secretory, cytoprotective and antioxidant agents. Besides their action as gastroprotectives, flavonoids also act in healing of gastric ulcers and additionally these polyphenolic compounds can be new alternatives for suppression or modulation of peptic ulcers associated with H. pylori. In this review, we have summarized the literature on ninety-five flavonoids with varying degrees of antiulcerogenic activity, confirming that flavonoids have a therapeutic potential for the more effective treatment of peptic ulcers.
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              Bioactivities from Marine Algae of the Genus Gracilaria

              Cynthia Layse F. de Almeida, Heloina de S. Falcão, Gedson Lima … (2011)
              Seaweeds are an important source of bioactive metabolites for the pharmaceutical industry in drug development. Many of these compounds are used to treat diseases like cancer, acquired immune-deficiency syndrome (AIDS), inflammation, pain, arthritis, as well as viral, bacterial, and fungal infections. This paper offers a survey of the literature for Gracilaria algae extracts with biological activity, and identifies avenues for future research. Nineteen species of this genus that were tested for antibacterial, antiviral, antifungal, antihypertensive, cytotoxic, spermicidal, embriotoxic, and anti-inflammatory activities are cited from the 121 references consulted.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Molecules
                Journal ID (iso-abbrev): Molecules
                Journal ID (publisher-id): molecules
                Title: Molecules
                Publisher: MDPI
                ISSN (Electronic): 1420-3049
                Publication date (Electronic): 11 October 2011
                Publication date Collection: October 2011
                Volume: 16
                Issue: 10
                Pages: 8515-8534
                Affiliations
                [1 ]Laboratory of Pharmaceutical Technology, Federal University of Paraiba, 58051-900, João Pessoa-PB, Brazil; Email: augustosouto@ 123456gmail.com (A.L.S.); josean@ 123456ltf.ufpb.br (J.F.T.); marcelosobral@ 123456ltf.ufpb.br (M.S.S.); margareth@ 123456ltf.ufpb.br (M.F.F.M.D.)
                [2 ]Department of Chemistry, Federal University of Paraíba, 58059-900, João Pessoa-PB, Brazil; Email: athayde-filho@ 123456quimica.ufpb.br
                Author notes
                [* ] Author to whom correspondence should be addressed; Email: jbarbosa@ 123456ltf.ufpb.br ; Tel.: +55-83-3216-7364; Fax: +55-83-3216-7364.
                Article
                Publisher ID: molecules-16-08515
                DOI: 10.3390/molecules16108515
                PMC ID: 6264344
                PubMed ID: 21989312
                SO-VID: b87487b7-48e2-4037-9d7b-2c29dba7b76f
                Copyright © © 2011 by the authors;
                License:

                licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/3.0/).

                History
                Date received : 22 July 2011
                Date revision received : 07 September 2011
                Date accepted : 26 September 2011
                Categories
                Subject: Review

                Keywords: alkaloids,anti-inflammatory activity,inflammation,experimental models,review
                Data availability:
                Keywords: alkaloids, anti-inflammatory activity, inflammation, experimental models, review

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