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      Carbohydrate Utilization in Exercising Muscle in Subtotally Nephrectomized Rabbits

      , , ,

      Nephron

      S. Karger AG

      Lactate, Muscle, Uremia, Exercise, Sugar, Alanine

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          Abstract

          Subtotally nephrectomized rabbits were compared with sham-operated controls. The isolated soleus muscle of one leg was exercised using controlled stimulus parameters at 1 Hz until the contraction tension (amplitude) was reduced by one half. The muscle was then quickly frozen in liquid nitrogen and analyzed for lactate, pyruvate, glycogen, alanine, glutamine and α-ketoglutarate. The resting leg was used as a control and similarly frozen and analyzed. The difference between resting and exercised muscle lactate and pyruvate concentration was significantly greater in experimental animals while muscle alanine and α-ketoglutarate concentrations were lower in the experimental animals. There was no difference in the time required to reach one half of the muscle contraction amplitude between experimental and control animals. Blood lactate levels rose in the experimental animals to a greater degree than in control animals, similar to that seen in human subjects with renal failure.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1990
          1990
          10 December 2008
          : 55
          : 2
          : 187-192
          Affiliations
          Departments of Medicine and Physiology, The George Washington University School of Medicine, Washington, D.C., USA
          Article
          185950 Nephron 1990;55:187–192
          10.1159/000185950
          2362634
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Alanine, Sugar, Exercise, Uremia, Muscle, Lactate

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