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Abstract
The release of endogenous dopamine (DA) from rat striatal tissue was studied in an
in vitro superfusion system following hormonal manipulations in vivo. Progesterone
treatment in estrogen-primed ovariectomized female rats potentiated DA release stimulated
either by amphetamine or potassium (K+). In addition, the amount of striatal DA released
in response to K+-stimulation was influenced by the light-dark cycle. We conclude
that striatal DA release is modulated by ovarian hormones, and suggest that ovarian
hormone modulation of presynaptic striatal DA activity may contribute to well-known
estrous cycle dependent variations in some non-reproductive behaviors.