Collagen-Binding Affinity of Beta-2-Microglobulin, a Preprotein of Hemodialysis-Associated Amyloidosis

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Abstract

β<sub>2</sub>-Microglobulin (B2M) is the amyloid preprotein that accumulates in amyloid osteoarthropathy associated with hemodialysis. To elucidate the mechanism of such amyloidogenesis, we investigated the interaction between B2M and collagen in vitro by solid-phase enzyme immunoassay. Soluble collagens which had been solidified on plastic plates were allowed to react sequentially with B2M, peroxidase-conjugated antibody to B2M, and the substrate. The collagen-binding activity was dependent on the concentration of B2M and collagen, respectively. These results suggest that the collagen-binding affinity of B2M plays an important role in amyloidogenesis.

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Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1989

Publication date (Print): 1989

Publication date (Electronic): 10 December 2008

Volume: 53

Issue: 1

Pages: 37-40

Affiliations

Department of Medicine II, Niigata University School of Medicine, Niigata, and Laboratory of Biochemistry, School of Food and Nutritional Sciences, University of Shizuoka, Japan

Article

Publisher ID: 185699 Other ID: Nephron 1989;53:37–40

DOI: 10.1159/000185699

PubMed ID: 2674742

SO-VID: b89c6616-7eaf-476f-9d3e-7fee0d48c65f

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 04 January 1989

Page count

Pages: 4

Product

Self URI (application/pdf): https://www.karger.com/Article/Pdf/185699

Self URI (text/html): https://www.karger.com/Article/FullText/185699

Self URI (journal page): https://www.karger.com/SubjectArea/Nephrology

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