Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary

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Abstract

Executive summary of the Global Strategy for Prevention, Diagnosis and Management of COPD 2023: the latest evidence-based strategy document from the Global Initiative for Chronic Obstructive Lung Disease (GOLD ) https://bit.ly/3KCaTGe

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Most cited references 199

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Frailty in Older Adults: Evidence for a Phenotype

L P Fried, C Tangen, J Walston … (2001)

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Reduced lung-cancer mortality with low-dose computed tomographic screening.

(2011)

The aggressive and heterogeneous nature of lung cancer has thwarted efforts to reduce mortality from this cancer through the use of screening. The advent of low-dose helical computed tomography (CT) altered the landscape of lung-cancer screening, with studies indicating that low-dose CT detects many tumors at early stages. The National Lung Screening Trial (NLST) was conducted to determine whether screening with low-dose CT could reduce mortality from lung cancer. From August 2002 through April 2004, we enrolled 53,454 persons at high risk for lung cancer at 33 U.S. medical centers. Participants were randomly assigned to undergo three annual screenings with either low-dose CT (26,722 participants) or single-view posteroanterior chest radiography (26,732). Data were collected on cases of lung cancer and deaths from lung cancer that occurred through December 31, 2009. The rate of adherence to screening was more than 90%. The rate of positive screening tests was 24.2% with low-dose CT and 6.9% with radiography over all three rounds. A total of 96.4% of the positive screening results in the low-dose CT group and 94.5% in the radiography group were false positive results. The incidence of lung cancer was 645 cases per 100,000 person-years (1060 cancers) in the low-dose CT group, as compared with 572 cases per 100,000 person-years (941 cancers) in the radiography group (rate ratio, 1.13; 95% confidence interval [CI], 1.03 to 1.23). There were 247 deaths from lung cancer per 100,000 person-years in the low-dose CT group and 309 deaths per 100,000 person-years in the radiography group, representing a relative reduction in mortality from lung cancer with low-dose CT screening of 20.0% (95% CI, 6.8 to 26.7; P=0.004). The rate of death from any cause was reduced in the low-dose CT group, as compared with the radiography group, by 6.7% (95% CI, 1.2 to 13.6; P=0.02). Screening with the use of low-dose CT reduces mortality from lung cancer. (Funded by the National Cancer Institute; National Lung Screening Trial ClinicalTrials.gov number, NCT00047385.).

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Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial

Harry J de Koning, Carlijn M van der Aalst, Pim A. de Jong … (2020)

There are limited data from randomized trials regarding whether volume-based, low-dose computed tomographic (CT) screening can reduce lung-cancer mortality among male former and current smokers.

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Author and article information

Journal

Journal ID (nlm-ta): Eur Respir J

Journal ID (iso-abbrev): Eur Respir J

Journal ID (publisher-id): ERJ

Journal ID (hwp): erj

Title: The European Respiratory Journal

Publisher: European Respiratory Society

ISSN (Print): 0903-1936

ISSN (Electronic): 1399-3003

Publication date Collection: April 2023

Publication date (Electronic): 03 April 2023

Volume: 61

Issue: 4

Electronic Location Identifier: 2300239

Affiliations

[1 ]Univ. Barcelona, Hospital Clinic, IDIBAPS and CIBERES, Barcelona, Spain

[2 ]Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

[3 ]Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA

[4 ]University of Exeter Medical School College of Medicine and Health University of Exeter, Exeter, UK

[5 ]South Texas Veterans Health Care System, University of Texas, San Antonio, TX, USA

[6 ]National Heart and Lung Institute, Imperial College London, London, UK

[7 ]McGill University Health Centre, McGill University, Montreal, QC, Canada

[8 ]University of Michigan, Ann Arbor, MI, USA

[9 ]Weill Cornell Medical Center/New York-Presbyterian Hospital, New York, NY, USA

[10 ]Hospital Universitario de Caracas Universidad Central de Venezuela Centro Médico de Caracas, Caracas, Venezuela

[11 ]Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK

[12 ]School of Clinical Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa

[13 ]University of Ferrara, Ferrara, Italy

[14 ]Respiratory Medicine Unit and Oxford Respiratory NIHR Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford, UK

[15 ]Pneumologie, Hôpital Cochin AP-HP.Centre, Université Paris, Paris, France

[16 ]Pulmocare Research and Education (PURE) Foundation, Pune, India

[17 ]St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada

[18 ]University of Manchester, Manchester, UK

[19 ]University Hospital, Birmingham, UK

[20 ]Universidad de la República, Hospital Maciel Montevideo, Montevideo, Uruguay

[21 ]Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University, German Center for Lung Research (DZL), Marburg, Germany

[22 ]Co-first authors

Author notes

Corresponding author: Alvar Agustí ( aagusti@ 123456clinic.cat )

Author information

Bartolome R. Celli https://orcid.org/0000-0002-7266-8371

Jean Bourbeau https://orcid.org/0000-0002-7649-038X

Kevin Mortimer https://orcid.org/0000-0002-8118-8871

Alberto Papi https://orcid.org/0000-0002-6924-4500

Nicolas Roche https://orcid.org/0000-0002-3162-5033

Article

Publisher ID: ERJ-00239-2023

DOI: 10.1183/13993003.00239-2023

PMC ID: 10066569

PubMed ID: 36858443

SO-VID: b8bdfce8-14e3-4a6e-a463-63fc95d675ee

License:

This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0. For commercial usage and reprints, please e-mail Diane Gern (dgern@thoracic.org)

History

Date received : 09 February 2023

Date accepted : 10 February 2023

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Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary

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Most cited references 199

Frailty in Older Adults: Evidence for a Phenotype

Reduced lung-cancer mortality with low-dose computed tomographic screening.

Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial

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Cited by 199

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