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      Modulatory effect of Ganoderma lucidum on expression of xenobiotic enzymes, oxidant-antioxidant and hormonal status in 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats

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          Abstract

          Background:

          Mushrooms are an important natural source represents a major and untapped potent pharmaceutical product. Ganoderma lucidum ( G. lucidum) an important medicinal mushroom has been shown to contain high amount of antioxidant. However, in vivo studies on G. lucidum fruiting bodies are lacking.

          Objectives:

          To determine the effects of G. lucidum fruiting bodies ethanolic extract (GLEet) on expression of xenobiotic enzymes, oxidant-antioxidant and hormonal status on 7,12-dimethyl benz[a]antheracene (DMBA) induced experimental breast cancer was investigated in female Sprague dawley rats.

          Materials and Methods:

          Cancer bearing female Sprague dawley rats was orally treated with GLEet (500mg/kg body weight) for 16 weeks. Incidence and tumor volume in each groups, and biochemical parameters were carried out in plasma, liver, and mammary tissues of animals. Histopathological and immunohistochemical analysis were also determined.

          Result:

          Oral administration of GLEet on tumor bearing animals significantly diminished the levels of lipid peroxidation thereby enhancing the nonenzymatic antioxidants and also positively regulated the estrogen receptor hormones level to near normal when compared with DMBA treated rats. Moreover, it also positively modulates the xenobiotic metabolizing enzymes. Therefore, the dietary administration of G. lucidum may be efficiently used as a chemopreventive agent against mammary carcinogenesis.

          Conclusion:

          We concluded that G. lucidum is a potent chemopreventive agent, thereby it offers maximum protection against DMBA-induced mammary carcinogenesis.

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          Most cited references56

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          Free Radicals in Biology and Medicine

          "This latest edition has been comprehensively rewritten and updated (over 80% of the text is new), whilst maintaining the clarity of its predecessor. There is expanded coverage of isoprostanes and related compounds, mechanisms of oxidative damage to DNA and proteins (and the repair of such damage), the free radical theory of ageing and the roles played by reactive species in signal transduction, cell death, human reproduction, and other important biological events. Greater emphasis has also been placed on the methods available to measure reactive species and oxidative damage (and their potential pitfalls), as well as the importance of antioxidants in the human diet." "This book is recommended as a comprehensive introduction to the field for students, clinicians and researchers, and an invaluable companion to all those interested in the role of free radicals in the life and medical sciences."--BOOK JACKET.
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            Formation of malonaldehyde from phospholipid arachidonate during microsomal lipid peroxidation.

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              Cellular defenses against damage from reactive oxygen species.

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                Author and article information

                Journal
                Pharmacogn Mag
                Pharmacogn Mag
                PM
                Pharmacognosy Magazine
                Medknow Publications & Media Pvt Ltd (India )
                0973-1296
                0976-4062
                Apr-Jun 2013
                : 9
                : 34
                : 167-175
                Affiliations
                [1] Department of Biochemistry and Biotechnology, Annamalai University, Tamil Nadu, India
                Author notes
                Address for correspondence: Dr. Sankaran Mirunalini, Department of Biochemistry and Biotechnology, Annamalai University, Tamil Nadu, India. E-mail: mirunasankar@ 123456gmail.com
                Article
                PM-9-167
                10.4103/0973-1296.111286
                3680858
                23772114
                b8cac00e-3980-4a56-8dcd-277f6aaba79e
                Copyright: © Pharmacognosy Magazine

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 02 April 2012
                : 26 May 2012
                : 30 April 2013
                Categories
                Original Article

                Pharmacology & Pharmaceutical medicine
                antioxidant,7,12-dimethylbenz(a)anthracene,ganoderma lucidum,mammary cancer,xenobiotic metabolizing enzymes

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