Fernando Laso-García: Role: Data curationRole: Formal analysisRole: InvestigationRole: Methodology
Jaime Ramos-Cejudo: Role: Data curationRole: Formal analysisRole: InvestigationRole: Methodology
Francisco Javier Carrillo-Salinas: Role: Data curationRole: Formal analysisRole: InvestigationRole: Methodology
Laura Otero-Ortega: Role: Formal analysisRole: InvestigationRole: Methodology
Ana Feliú: Role: Formal analysisRole: InvestigationRole: Methodology
MariCarmen Gómez-de Frutos: Role: InvestigationRole: Methodology
Miriam Mecha: Role: Formal analysisRole: Methodology
Exuperio Díez-Tejedor: Role: InvestigationRole: Supervision
Carmen Guaza: Role: Formal analysisRole: MethodologyRole: Writing – original draft
María Gutiérrez-Fernández:
ORCID: http://orcid.org/0000-0002-6615-4729
Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
SupervisionRole: Writing – review & editing
Johannes Boltze: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
19
September
2018
Publication date Collection: 2018
Volume: 13
Issue: 9
Electronic Location Identifier: e0202590
Affiliations
[1
]
Neuroscience and Cerebrovascular Research Laboratory, Department of Neurology and
Stroke Center, La Paz University Hospital, Neuroscience Area of IdiPAZ Health Research
Institute, Autonomous University of Madrid, Madrid, Spain
[2
]
Functional and Systems Neurobiology Department, Neuroimmunology Group, Cajal Institute,
Madrid, Spain
Fraunhofer Research Institution of Marine Biotechnology, GERMANY
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-18-04980
DOI: 10.1371/journal.pone.0202590
PMC ID: 6145506
PubMed ID: 30231069
SO-VID: b8edd4d2-23d0-442a-b579-666c8956609c
Copyright © © 2018 Laso-García et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Fondo Europeo de
Desarrollo Regional (FEDER)
Award ID: RD12/0032/0008
Award Recipient
:
Carmen Guaza
Funded by: Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Fondo Europeo de
Desarrollo Regional (FEDER)
Award ID: RD16/0015/0021
Award Recipient
:
Carmen Guaza
This study was supported by Red Española de Esclerosis Múltiple Grants RD12/0032/0008
and RD16/0015/0021 (sponsored by the Fondo de Investigación Sanitaria, Instituto de
Salud Carlos III, Fondo Europeo de Desarrollo Regional [FEDER]) to C.G. The funders
had no role in study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Clinical Medicine
Subject:
Clinical Immunology
Subject:
Autoimmune Diseases
Subject:
Multiple Sclerosis
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Clinical Immunology
Subject:
Autoimmune Diseases
Subject:
Multiple Sclerosis
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Clinical Immunology
Subject:
Autoimmune Diseases
Subject:
Multiple Sclerosis
Subject:
Medicine and Health Sciences
Subject:
Neurology
Subject:
Demyelinating Disorders
Subject:
Multiple Sclerosis
Subject:
Medicine and Health Sciences
Subject:
Neurology
Subject:
Neurodegenerative Diseases
Subject:
Multiple Sclerosis
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Nervous System
Subject:
Neuroanatomy
Subject:
Spinal Cord
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Nervous System
Subject:
Neuroanatomy
Subject:
Spinal Cord
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Neuroanatomy
Subject:
Spinal Cord
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Cytokines
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Cytokines
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System
Subject:
Innate Immune System
Subject:
Cytokines
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System
Subject:
Innate Immune System
Subject:
Cytokines
Subject:
Biology and Life Sciences
Subject:
Developmental Biology
Subject:
Molecular Development
Subject:
Cytokines
Subject:
Research and Analysis Methods
Subject:
Immunologic Techniques
Subject:
Immunoassays
Subject:
Immunofluorescence
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Nervous System
Subject:
Central Nervous System
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Nervous System
Subject:
Central Nervous System
Subject:
Medicine and Health Sciences
Subject:
Infectious Diseases
Subject:
Infectious Diseases of the Nervous System
Subject:
Encephalomyelitis
Subject:
Medicine and Health Sciences
Subject:
Neurology
Subject:
Infectious Diseases of the Nervous System
Subject:
Encephalomyelitis
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Structures and Organelles
Subject:
Vesicles
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Stem Cells
Subject:
Mesenchymal Stem Cells