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      The prevention and handling of the missing data

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          Abstract

          Even in a well-designed and controlled study, missing data occurs in almost all research. Missing data can reduce the statistical power of a study and can produce biased estimates, leading to invalid conclusions. This manuscript reviews the problems and types of missing data, along with the techniques for handling missing data. The mechanisms by which missing data occurs are illustrated, and the methods for handling the missing data are discussed. The paper concludes with recommendations for the handling of missing data.

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          Most cited references15

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          Missing data analysis: making it work in the real world.

          This review presents a practical summary of the missing data literature, including a sketch of missing data theory and descriptions of normal-model multiple imputation (MI) and maximum likelihood methods. Practical missing data analysis issues are discussed, most notably the inclusion of auxiliary variables for improving power and reducing bias. Solutions are given for missing data challenges such as handling longitudinal, categorical, and clustered data with normal-model MI; including interactions in the missing data model; and handling large numbers of variables. The discussion of attrition and nonignorable missingness emphasizes the need for longitudinal diagnostics and for reducing the uncertainty about the missing data mechanism under attrition. Strategies suggested for reducing attrition bias include using auxiliary variables, collecting follow-up data on a sample of those initially missing, and collecting data on intent to drop out. Suggestions are given for moving forward with research on missing data and attrition.
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            Inference and missing data

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              Multiple Imputation after 18+ Years

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                Author and article information

                Journal
                Korean J Anesthesiol
                Korean J Anesthesiol
                KJAE
                Korean Journal of Anesthesiology
                The Korean Society of Anesthesiologists
                2005-6419
                2005-7563
                May 2013
                24 May 2013
                : 64
                : 5
                : 402-406
                Affiliations
                Department of Anesthesiology and Pain Medicine, Chung-Ang Universtiy College of Medicine, Seoul, Korea.
                Author notes
                Corresponding author: Hyun Kang, M.D., Ph.D., Department of Anesthesiology and Pain Medicine, Chung-Ang Universtiy College of Medicine, 224-1, Heuksuk-dong, Dongjak-gu, Seoul 156-756, Korea. Tel: 82-2-6299-2571, Fax: 82-2-6299-2585, roman00@ 123456naver.com
                Article
                10.4097/kjae.2013.64.5.402
                3668100
                23741561
                b8ff2289-09eb-4bc2-8ea8-5f7148c18edf
                Copyright © the Korean Society of Anesthesiologists, 2013

                This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 13 February 2013
                : 20 February 2013
                Categories
                Review Article

                Anesthesiology & Pain management
                expectation-maximization,imputation,missing data,sensitivity analysis

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