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      Favipiravir and Ribavirin Treatment of Epidemiologically Linked Cases of Lassa Fever

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          Abstract

          Two patients with Lassa fever are described who are the first human cases treated with a combination of ribavirin and favipiravir. Both patients survived but developed transaminitis and had prolonged detectable virus RNA in blood and semen, suggesting that the possibility of sexual transmission of Lassa virus should be considered.

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          Author and article information

          Journal
          9203213
          1135
          Clin Infect Dis
          Clin. Infect. Dis.
          Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
          1058-4838
          1537-6591
          8 September 2017
          01 September 2017
          13 November 2017
          : 65
          : 5
          : 855-859
          Affiliations
          [1 ]Division of Infectious Diseases, Emory University, Atlanta, Georgia
          [2 ]Department of Medicine, Infectious Diseases Unit, Goethe University Hospital, Frankfurt/Main, Germany
          [3 ]Samaritan’s Purse, Togo, West Africa
          [4 ]Emory Healthcare, Atlanta, Georgia
          [5 ]Hospital of Hope, Mango, Togo
          [6 ]Institute of Virology and Germany Centre for Infectious Diseases Research (DZIF), Gießen-Marburg-Langen, Philipps University, Marburg, Germany
          [7 ]US Centers for Disease Control and Prevention, Viral Special Pathogens Branch, Atlanta, Georgia
          [8 ]Institute of Medical Virology, University Hospital, Frankfurt, Germany
          [9 ]Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia
          Author notes
          Correspondence: C. S. Kraft, Emory University Hospital, Department of Pathology and Laboratory Medicine, 1364 Clifton Rd NE, F145C, Atlanta, GA 30322 ( colleen.kraft@ 123456emory.edu )
          [a]

          V. N. R., G. K., C. S. K., and T. W. contributed equally to this work.

          [b]

          Members of the Emory Serious Communicable Diseases Unit are listed after the References.

          Article
          PMC5682919 PMC5682919 5682919 hhspa904566
          10.1093/cid/cix406
          5682919
          29017278
          b914559a-1a56-4c0e-aac8-fcb518dbfa96

          For permissions, journals.permissions@ 123456oup.com

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          Categories
          Article

          favipiravir,ribavirin,Togo,Lassa
          favipiravir, ribavirin, Togo, Lassa

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