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      Abortive transformation of rat 3Y1 cells by simian virus 40: Viral function overcoming inhibition of cellular proliferation under various conditions of culture

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      Virology

      Elsevier BV

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          Abstract

          Resting cultures of nonpermissive rat 3Y1 cells were infected with simian and T antigen expression and entry into S phase were examined under various conditions of culture. In the complete absence of serum from the medium or at an extremely high cell density, the cells delayed T antigen expression and entry into S phase, leaving the interval between the two events constant. Results using the viral mutants deleted in the coding region for the small t antigen ruled out the role of this antigen in induction of S phase. From these and other results presented, we conclude that the large T antigen induces S phase with the same efficiency under different conditions of cultures. We also present the evidence that the large T antigen function is required and is sufficient for entry into S phase in the second as well as in the first generation.

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          Author and article information

          Journal
          Virology
          Virology
          Elsevier BV
          00426822
          February 1984
          February 1984
          : 133
          : 1
          : 35-45
          Article
          10.1016/0042-6822(84)90423-9
          6322436
          © 1984

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