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      Cellular functions of Rab GTPases at a glance.

      1 , 2
      Journal of cell science
      GTPase, Rab, Traffic

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          Abstract

          Rab GTPases control intracellular membrane traffic by recruiting specific effector proteins to restricted membranes in a GTP-dependent manner. In this Cell Science at a Glance and the accompanying poster, we highlight the regulation of Rab GTPases by proteins that control their membrane association and activation state, and provide an overview of the cellular processes that are regulated by Rab GTPases and their effectors, including protein sorting, vesicle motility and vesicle tethering. We also discuss the physiological importance of Rab GTPases and provide examples of diseases caused by their dysfunctions.

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          Author and article information

          Journal
          J. Cell. Sci.
          Journal of cell science
          1477-9137
          0021-9533
          Sep 1 2015
          : 128
          : 17
          Affiliations
          [1 ] Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, Oslo N-0379, Norway Department for Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, Oslo N-0379, Norway.
          [2 ] Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, Oslo N-0379, Norway Department for Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, Oslo N-0379, Norway stenmark@ulrik.uio.no.
          Article
          jcs.166074
          10.1242/jcs.166074
          26272922
          b91e4de3-36f6-4ed6-8b1c-3c710d7e7041
          © 2015. Published by The Company of Biologists Ltd.
          History

          GTPase,Rab,Traffic
          GTPase, Rab, Traffic

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