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      Effects of Exercise Training in Predialytic Uremic Patients

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          Abstract

          We examined the effects of physical training in 10 predialytic uremic patients (7 men, 3 women, mean age 47 ± 8 years) with an average glomerular filtration (GFR) of 15 ± 7 ml/min × 1,73 m<sup>2</sup>. All 10 patients participated in an exercise programme 3 times/week for 3 months and were compared to a control group of 9 patients with comparable baseline variables. The exercise group increased its maximal exercise capacity measured by standardized exercise test on a bicycle ergometer, from an average 159 ± 49 to 174 ± 57 W (p < 0.01). They also showed a decrease in heart rate at equal load (138 ± 29–123 ± 18 beats/min, p < 0.05). The control group did not change its exercise capacity (171 ± 60 and 171 ± 65 W, respectively, NS), nor its heart rate at equal load (124 ± 24 and 123 ± 24 beats/min, respectively, NS). Thigh muscular function assessed by static endurance increased from a median 77 s (range 27–197) to 113 s (range 66–201), p < 0.002. Dynamic muscular endurance increased from a median number of 41 movements (range 28–105) to 93 movements (range 45–139), p < 0.001. The corresponding figures for the controls were: static endurance 60 (range 20–209) and 47 s (range 9–203), respectively, NS; dynamic endurance 53 (range 19–190) and 43 movements (range 10–126), respectively, NS. Total hemoglobin, blood volume, GFR, blood pressure and echocardiographic variables remained unchanged during the observation period. We conclude that in predialytic uremic patients, physical training improves exercise capacity mainly due to an improved muscular function.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1991
          1991
          11 December 2008
          : 59
          : 1
          : 84-89
          Affiliations
          aDivision of Nephrology and bCardiology, Department of Medicine; cDepartment of Clinical Physiology, and dDepartment of Physical Medicine and Rehabilitation, Karolinska Hospital, Stockholm, Sweden
          Article
          186524 Nephron 1991;59:84–89
          10.1159/000186524
          1944753
          © 1991 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

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