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      Wegener’s Granulomatosis with Antiproteinase-3 Antibodies Occurring after Hodgkin’s Disease

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          Abstract

          We describe the first association between Hodgkin’s lymphoma and Wegener’s granulomatosis, heralded by renal involvement. A 43-year-old man developed rapidly progressive glomerulonephritis requiring chronic hemodialysis 8 months after remission of Hodgkin’s lymphoma. At that moment, no extrarenal involvement was found, despite extensive investigation. Antineutrophil cytoplasm antibodies were positive, without specificity for proteinase-3 or myeloperoxydase. Six months after beginning hemodialysis, multiple pulmonary nodules appeared, along with rapid clinical worsening. A surgical biopsy was performed which disclosed a giant cell granuloma. Antimyeloperoxydase antibodies remained negative, whereas proteinase-3 antibodies became positive. Wegener’s granulomatosis was diagnosed and treatment with cyclophosphamide and steroids was started. Clinical and radiological improvement occurred promptly. Eleven months after treatment, both Wegener’s disease and Hodgkin’s lymphoma remained in remission.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1993
          1993
          12 December 2008
          : 64
          : 3
          : 456-461
          Affiliations
          aDepartment of Nephrology, bDepartment of Hematology, and cDepartment of Pathology, Hôpital Edouard-Herriot, dDepartment of Pneumology, and eDepartment of Pathology, Hôpital Cardio-Pneumologique, Bron, France
          Article
          187371 Nephron 1993;64:456–461
          10.1159/000187371
          8341394
          © 1993 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Case Report

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