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      Wegener’s Granulomatosis with Antiproteinase-3 Antibodies Occurring after Hodgkin’s Disease

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          We describe the first association between Hodgkin’s lymphoma and Wegener’s granulomatosis, heralded by renal involvement. A 43-year-old man developed rapidly progressive glomerulonephritis requiring chronic hemodialysis 8 months after remission of Hodgkin’s lymphoma. At that moment, no extrarenal involvement was found, despite extensive investigation. Antineutrophil cytoplasm antibodies were positive, without specificity for proteinase-3 or myeloperoxydase. Six months after beginning hemodialysis, multiple pulmonary nodules appeared, along with rapid clinical worsening. A surgical biopsy was performed which disclosed a giant cell granuloma. Antimyeloperoxydase antibodies remained negative, whereas proteinase-3 antibodies became positive. Wegener’s granulomatosis was diagnosed and treatment with cyclophosphamide and steroids was started. Clinical and radiological improvement occurred promptly. Eleven months after treatment, both Wegener’s disease and Hodgkin’s lymphoma remained in remission.

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          S. Karger AG
          12 December 2008
          : 64
          : 3
          : 456-461
          aDepartment of Nephrology, bDepartment of Hematology, and cDepartment of Pathology, Hôpital Edouard-Herriot, dDepartment of Pneumology, and eDepartment of Pathology, Hôpital Cardio-Pneumologique, Bron, France
          187371 Nephron 1993;64:456–461
          © 1993 S. Karger AG, Basel

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          Pages: 6
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