Plasma MicroRNA-21 Predicts Postoperative Pulmonary Complications in Patients Undergoing Pneumoresection

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Abstract

Postoperative pulmonary complication (PPC) remains the most common postoperative complication in patients undergoing noncardiac thoracic surgery. We conducted the clinical study to determine the diagnostic role of miRNA-21 in noncardiac thoracic surgery. 368 patients undergoing noncardiac thoracic surgery were recruited. Blood samples were collected before anesthesia and 2 hours after incision during surgery for RT-PCR measurement of miRNA-21. PPC occurrence, extrapulmonary complications, duration of ICU stay, and death within 1 year were evaluated. The overall rate of PPCs following surgery was 10.32%. A high relative miRNA-21 level was an independent risk factor for PPCs within 7 days (OR, 2.69; 95% CI, 1.25–5.66; and P < 0.001). High miRNA-21 was also associated with an increased risk of extrapulmonary complications (OR, 3.62; 95% CI, 2.26–5.81; and P < 0.001), prolonged ICU stay (OR, 6.54; 95% CI, 2.26–18.19; and P < 0.001), increased death within 30 days (OR, 6.17; 95% CI, 2.11–18.08; and P < 0.001), and death within 1 year (OR, 7.30; 95% CI, 2.76–19.28; and P < 0.001). In summary, plasma miRNA-21 may serve as a novel biomarker of PPCs for patients undergoing noncardiac thoracic surgery.

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Most cited references 25

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Author and article information

Journal

Journal ID (nlm-ta): Mediators Inflamm

Journal ID (iso-abbrev): Mediators Inflamm

Journal ID (publisher-id): MI

Title: Mediators of Inflammation

Publisher: Hindawi Publishing Corporation

ISSN (Print): 0962-9351

ISSN (Electronic): 1466-1861

Publication date (Print): 2016

Publication date (Electronic): 12 May 2016

Volume: 2016

Electronic Location Identifier: 3591934

Affiliations

Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

Author notes

*Liqun Yang: lqyang72721@ 123456126.com and

*Hui Zhu: huizhuanes@ 123456qq.com

Academic Editor: Ronald Gladue

Article

DOI: 10.1155/2016/3591934

PMC ID: 4880696

PubMed ID: 27293316

SO-VID: b94bcff3-0024-4703-bca3-74dc37a48096

License:

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.