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      Contractile Responses of Caudal Arteries from Diabetic Rats to Adrenergic Nerve Stimulation

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          Abstract

          The effect of 12-14 weeks streptozotocin-induced diabetes on contractile responses of the highly innervated caudal artery to adrenergic nerve stimulation was studied. The maximum contractile response and sensitivity (as reflected by the pD<sub>2</sub> value) to noradrenaline (NA) was significantly greater in diabetic than in control caudal arteries. The maximum contractile response, but not sensitivity, to tyramine was significantly enhanced in diabetic compared with control caudal arteries when expressed as stress (mN/mm<sup>2</sup>), but not when expressed as a percentage of the maximum NA response obtained previously in the same tissues. No significant difference was detected between the responses of control and diabetic caudal arteries to electrical field stimulation of adrenergic nerves, when expressed either as stress or as a percentage of the corresponding NA response. Pretreatment with phentolamine markedly inhibited the contractile responses to field stimulation of both diabetic and control caudal arteries, while 6-hydroxydopamine essentially abolished responses to electrical field stimulation and tyramine in both tissues. Finally, pretreatment with hydrocortisone, timolol, and desipramine increased sensitivity to NA in control and diabetic caudal arteries by a similar magnitude. Thus, the enhanced contractile responses of caudal arteries from diabetic rats to NA do not appear to be associated with the development of autonomic neuropathy.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1994
          1994
          23 September 2008
          : 31
          : 1
          : 25-32
          Affiliations
          Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, B.C., Canada
          Article
          159028 J Vasc Res 1994;31:25–32
          10.1159/000159028
          8274623
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Research Paper

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