6
views
0
recommends
+1 Recommend
2 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      SARS‐CoV‐2 pandemic and repercussions for male infertility patients: A proposal for the individualized provision of andrological services

      article-commentary
      1 , 2 , 3 , , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 1 , 1 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 3 , 27 , 34 , 35 , 36 , 37
      Andrology
      John Wiley and Sons Inc.
      azoospermia, male infertility, opinion, SARS‐CoV‐2, semen analysis, sperm banking, systemic auto‐immune diseases

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The prolonged lockdown of health facilities providing non‐urgent gamete cryopreservation—as currently recommended by many reproductive medicine entities and regulatory authorities due to the SARS‐CoV‐2 pandemic will be detrimental for subgroups of male infertility patients. We believe the existing recommendations should be promptly modified and propose that the same permissive approach for sperm banking granted for men with cancer is expanded to other groups of vulnerable patients. These groups include infertility patients (eg, azoospermic and cryptozoospermic) undergoing medical or surgical treatment to improve sperm quantity and quality, as well as males of reproductive age affected by inflammatory and systemic auto‐immune diseases who are about to start treatment with gonadotoxic drugs or who are under remission. In both scenarios, the “fertility window” may be transitory; postponing diagnostic semen analysis and sperm banking in these men could compromise the prospects of biological parenthood. Moreover, we provide recommendations on how to continue the provision of andrological services in a considered manner and a safe environment. Our opinion is timely and relevant given the fact that fertility services are currently rated as of low priority in most countries.

          Related collections

          Most cited references45

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID-19) Epidemic among the General Population in China

          Background: The 2019 coronavirus disease (COVID-19) epidemic is a public health emergency of international concern and poses a challenge to psychological resilience. Research data are needed to develop evidence-driven strategies to reduce adverse psychological impacts and psychiatric symptoms during the epidemic. The aim of this study was to survey the general public in China to better understand their levels of psychological impact, anxiety, depression, and stress during the initial stage of the COVID-19 outbreak. The data will be used for future reference. Methods: From 31 January to 2 February 2020, we conducted an online survey using snowball sampling techniques. The online survey collected information on demographic data, physical symptoms in the past 14 days, contact history with COVID-19, knowledge and concerns about COVID-19, precautionary measures against COVID-19, and additional information required with respect to COVID-19. Psychological impact was assessed by the Impact of Event Scale-Revised (IES-R), and mental health status was assessed by the Depression, Anxiety and Stress Scale (DASS-21). Results: This study included 1210 respondents from 194 cities in China. In total, 53.8% of respondents rated the psychological impact of the outbreak as moderate or severe; 16.5% reported moderate to severe depressive symptoms; 28.8% reported moderate to severe anxiety symptoms; and 8.1% reported moderate to severe stress levels. Most respondents spent 20–24 h per day at home (84.7%); were worried about their family members contracting COVID-19 (75.2%); and were satisfied with the amount of health information available (75.1%). Female gender, student status, specific physical symptoms (e.g., myalgia, dizziness, coryza), and poor self-rated health status were significantly associated with a greater psychological impact of the outbreak and higher levels of stress, anxiety, and depression (p < 0.05). Specific up-to-date and accurate health information (e.g., treatment, local outbreak situation) and particular precautionary measures (e.g., hand hygiene, wearing a mask) were associated with a lower psychological impact of the outbreak and lower levels of stress, anxiety, and depression (p < 0.05). Conclusions: During the initial phase of the COVID-19 outbreak in China, more than half of the respondents rated the psychological impact as moderate-to-severe, and about one-third reported moderate-to-severe anxiety. Our findings identify factors associated with a lower level of psychological impact and better mental health status that can be used to formulate psychological interventions to improve the mental health of vulnerable groups during the COVID-19 epidemic.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records

            Summary Background Previous studies on the pneumonia outbreak caused by the 2019 novel coronavirus disease (COVID-19) were based on information from the general population. Limited data are available for pregnant women with COVID-19 pneumonia. This study aimed to evaluate the clinical characteristics of COVID-19 in pregnancy and the intrauterine vertical transmission potential of COVID-19 infection. Methods Clinical records, laboratory results, and chest CT scans were retrospectively reviewed for nine pregnant women with laboratory-confirmed COVID-19 pneumonia (ie, with maternal throat swab samples that were positive for severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) who were admitted to Zhongnan Hospital of Wuhan University, Wuhan, China, from Jan 20 to Jan 31, 2020. Evidence of intrauterine vertical transmission was assessed by testing for the presence of SARS-CoV-2 in amniotic fluid, cord blood, and neonatal throat swab samples. Breastmilk samples were also collected and tested from patients after the first lactation. Findings All nine patients had a caesarean section in their third trimester. Seven patients presented with a fever. Other symptoms, including cough (in four of nine patients), myalgia (in three), sore throat (in two), and malaise (in two), were also observed. Fetal distress was monitored in two cases. Five of nine patients had lymphopenia (<1·0 × 10⁹ cells per L). Three patients had increased aminotransferase concentrations. None of the patients developed severe COVID-19 pneumonia or died, as of Feb 4, 2020. Nine livebirths were recorded. No neonatal asphyxia was observed in newborn babies. All nine livebirths had a 1-min Apgar score of 8–9 and a 5-min Apgar score of 9–10. Amniotic fluid, cord blood, neonatal throat swab, and breastmilk samples from six patients were tested for SARS-CoV-2, and all samples tested negative for the virus. Interpretation The clinical characteristics of COVID-19 pneumonia in pregnant women were similar to those reported for non-pregnant adult patients who developed COVID-19 pneumonia. Findings from this small group of cases suggest that there is currently no evidence for intrauterine infection caused by vertical transmission in women who develop COVID-19 pneumonia in late pregnancy. Funding Hubei Science and Technology Plan, Wuhan University Medical Development Plan.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study

              Summary Background In December, 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China. The number of affected pregnant women is increasing, but scarce information is available about the clinical features of COVID-19 in pregnancy. This study aimed to clarify the clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19. Methods In this retrospective, single-centre study, we included all pregnant women with COVID-19 who were admitted to Tongji Hospital in Wuhan, China. Clinical features, treatments, and maternal and fetal outcomes were assessed. Findings Seven patients, admitted to Tongji Hospital from Jan 1, to Feb 8, 2020, were included in our study. The mean age of the patients was 32 years (range 29–34 years) and the mean gestational age was 39 weeks plus 1 day (range 37 weeks to 41 weeks plus 2 days). Clinical manifestations were fever (six [86%] patients), cough (one [14%] patient), shortness of breath (one [14%] patient), and diarrhoea (one [14%] patient). All the patients had caesarean section within 3 days of clinical presentation with an average gestational age of 39 weeks plus 2 days. The final date of follow-up was Feb 12, 2020. The outcomes of the pregnant women and neonates were good. Three neonates were tested for SARS-CoV-2 and one neonate was infected with SARS-CoV-2 36 h after birth. Interpretation The maternal, fetal, and neonatal outcomes of patients who were infected in late pregnancy appeared very good, and these outcomes were achieved with intensive, active management that might be the best practice in the absence of more robust data. The clinical characteristics of these patients with COVID-19 during pregnancy were similar to those of non-pregnant adults with COVID-19 that have been reported in the literature. Funding National Natural Science Foundation of China, Hubei Provincial Natural Science Foundation of China.
                Bookmark

                Author and article information

                Contributors
                s.esteves@androfert.com.br
                Journal
                Andrology
                Andrology
                10.1111/(ISSN)2047-2927
                ANDR
                Andrology
                John Wiley and Sons Inc. (Hoboken )
                2047-2919
                2047-2927
                22 May 2020
                : 10.1111/andr.12809
                Affiliations
                [ 1 ] ANDROFERT, Andrology and Human Reproduction Clinic Campinas Brazil
                [ 2 ] Department of Surgery (Division of Urology) University of Campinas (UNICAMP) Campinas Brazil
                [ 3 ] Faculty of Health Aarhus University Aarhus Denmark
                [ 4 ] Department of Medical Physiopathology University of Rome "La Sapienza" Rome Italy
                [ 5 ] IVI Foundation Health Research Institute La Fe Valencia Spain
                [ 6 ] Centro ANDROGEN La Coruña Spain
                [ 7 ] Division of Urology Department of Surgery St. Mary’s Hospital McGill University Montreal QC Canada
                [ 8 ] Andrology Service Procrea Swiss Fertility Center Lugano Switzerland
                [ 9 ] Andrology and IVF Department San Carlo Cinic Paderno Dugnano/Milano Italy
                [ 10 ] Centre for Human Reproductive Science IMSR College of Medical and Dental Sciences University of Birmingham Birmingham UK
                [ 11 ] Birmingham Women's Fertility Centre Birmingham Women's & Children's NHS Foundation Trust Birmingham UK
                [ 12 ] Queens University Belfast Belfast UK
                [ 13 ] Examenlab Ltd. Belfast UK
                [ 14 ] ANOVA Karolinska University Hospital and Karolinska Institutet Stockholm Sweden
                [ 15 ] Department of Urology Hamad Medical Corporation Doha Qatar
                [ 16 ] Weill Cornell Medicine‐Qatar Doha Qatar
                [ 17 ] Department of Surgery Union Hospital Hong Kong Hong Kong
                [ 18 ] S.H. Ho Urology Centre Department of Surgery The Chinese University of Hong Kong Hong Kong Hong Kong
                [ 19 ] Urology/Andrology Unit Saúde Atlântica Clínica do Dragão Porto Portugal
                [ 20 ] Androscience, Science and Innovation Center in Andrology and High‐Complex Clinical and Andrology Laboratory São Paulo Brazil
                [ 21 ] Division of Urology University of São Paulo São Paulo Brazil
                [ 22 ] Men’s Health Study Group Institute for Advanced Studies University of São Paulo São Paulo Brazil
                [ 23 ] Reproductive Toxicology Unit Department of Pathology University of São Paulo São Paulo Brazil
                [ 24 ] Cabinet D’Andrologie Victor Hugo American Hospital of Paris Reproductive Center Paris France
                [ 25 ] Human Reproduction Center Division of Urology University of São Paulo São Paulo Brazil
                [ 26 ] Edinburgh Assisted Conception Programme EFREC Royal Infirmary of Edinburgh Edinburgh UK
                [ 27 ] Fertility Clinic Skive Skive Regional Hospital Skive Denmark
                [ 28 ] IVF Laboratory Al Saad Specialist Hospitals Jeddah Saudi Arabia
                [ 29 ] Reproductive Medicine and Genetic Unit GEBRI Sadat City Egypt
                [ 30 ] Division of Reproductive Medicine and Andrology Jindal Hospital Meerut India
                [ 31 ] PUR Clinic and University of Central Florida Clermont FL USA
                [ 32 ] Department of Urology Miller School of Medicine University of Miami Miami FL USA
                [ 33 ] Department of Neuroscience, Reproductive Science and Odontostomatology University of Naples Federico II Naples Italy
                [ 34 ] PIVET Medical Centre Perth WA Australia
                [ 35 ] Curtin University Perth WA Australia
                [ 36 ] Cairns Fertility Centre Cairns QLD Australia
                [ 37 ] Andrology Center Department of Urology Cleveland Clinic Cleveland OH USA
                Author notes
                [*] [* ] Correspondence

                Sandro C. Esteves, ANDROFERT, Andrology and Human Reproduction Clinic, Av. Dr. Heitor Penteado, 1463, Campinas 13075‐460, SP, Brazil.

                Email: s.esteves@ 123456androfert.com.br

                Author information
                https://orcid.org/0000-0002-1313-9680
                https://orcid.org/0000-0002-6943-2966
                https://orcid.org/0000-0001-8271-5218
                https://orcid.org/0000-0002-2194-5578
                https://orcid.org/0000-0003-1431-1777
                https://orcid.org/0000-0003-2833-8970
                https://orcid.org/0000-0001-5665-1572
                https://orcid.org/0000-0002-4709-5807
                https://orcid.org/0000-0001-7423-6241
                https://orcid.org/0000-0003-2520-6833
                https://orcid.org/0000-0002-6452-0502
                https://orcid.org/0000-0002-5465-4304
                https://orcid.org/0000-0003-3772-1357
                https://orcid.org/0000-0002-7698-8823
                https://orcid.org/0000-0001-5751-9506
                https://orcid.org/0000-0002-8088-8710
                https://orcid.org/0000-0001-6847-8826
                https://orcid.org/0000-0003-1387-7904
                https://orcid.org/0000-0001-9116-020X
                https://orcid.org/0000-0001-6884-5366
                https://orcid.org/0000-0002-9583-3683
                https://orcid.org/0000-0003-0585-1026
                Article
                ANDR12809
                10.1111/andr.12809
                7267121
                32357288
                b950e5a0-94b7-43d6-9cbd-64ce62b0a0ef
                © 2020 American Society of Andrology and European Academy of Andrology

                This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

                History
                : 22 April 2020
                : 25 April 2020
                : 27 April 2020
                Page count
                Figures: 1, Tables: 0, Pages: 9, Words: 13533
                Categories
                Opinion Article
                Opinion Article
                Custom metadata
                2.0
                corrected-proof
                Converter:WILEY_ML3GV2_TO_JATSPMC version:5.8.3 mode:remove_FC converted:03.06.2020

                azoospermia,male infertility,opinion,sars‐cov‐2,semen analysis,sperm banking,systemic auto‐immune diseases

                Comments

                Comment on this article