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      Stable Renal Function in Insulin-Dependent Diabetes mellitus 10 Years after Nephrotic Range Proteinuria



      S. Karger AG

      Diabetic nephropathy, Nephrotic proteinuria, Prognosis, Insulin-dependent diabetes mellitus

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          It has been considered unlikely that patients with insulin-dependent diabetes and diabetic nephropathy with nephrotic range proteinuria can substantially reduce proteinuria and continue for many years without further loss of renal function. We present a patient who had the diagnosis of insulin-dependent diabetes made at age 15, had his first of 6 laser treatments for proliferative and hemorrhagic retinopathy at age 27 and was found to have nephrotic range proteinuria and edema with hypertension at age 29, when results of a renal biopsy were typical of diabetic nephropathy. Ten years later, with the last 5.5 years on ACE inhibitors, proteinuria has been < 0.65 g/24 h for 2 years and recently 0.22 g, serum creatinine is unchanged at 90 to 102 μmol/l, DTPA GFR is 104 ml/min and retinopathy has remained stable without laser therapy for 7 years. Blood pressure on clinic visits has averaged 126/74 for the last 8 years. This duration of stable renal function and the major decrease in proteinuria after being in the neprotic range is very rare in reports, if not unique.

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          Author and article information

          S. Karger AG
          18 December 2008
          : 72
          : 1
          : 86-92
          Memorial University and General Hospital, St. John’s, NF, Canada
          188812 Nephron 1996;72:86–92
          © 1996 S. Karger AG, Basel

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          Pages: 7
          Case Report


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