Solute Transport in Comparable Surface Area Dialyzers

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Abstract

The present study compared clearance (K) for urea (U), uric acid (Ua), and BSP in relatively equal surface area dialyzers, EX-29 to dual EX-21 in parallel (DEX-21) at QB and QD 300 ml/min, and hollow fiber kidney model 5 (HFK-5) to dual HFK model 4 in series (DHFK-4) at QB 200, QD 500 ml/min. KU was 158 ± 20 ml/min, 129 ± 22; KUa was 106 ± 10,96 ± 5, and KBSP was 80 ± 11 and 67 ± 12 (p < 0.01) for EX-29 and DEX-21, respectively. KU was 173 ± 8 ml/min, 159 ± 6; KUa was 131 ± 6, 117 ± 8, and KBSP was 65 ± 9 and 56 ± 7 (p < 0.01) for HFK-5 and DHFK-4, respectively. Comparable changes in outlet pressure had a varied effect on ultrafiltration and solute transport. 3-hour hemodialysis in the same patients showed that EX-29 was better tolerated than DEX-21. The data suggest that dialyzer designs with the same membrane of equal surface area may significantly affect K for both small and middle molecular weight solutes. Comparable changes in outlet pressure may have a varied effect on K in different designs. Due to these variations, comparison of dialysis schedules with different dialyzers on the basis of the square meter hour dialysis to prove validity of middle molecule hypothesis should be interpreted cautiously.

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1976

Publication date (Print): 1976

Publication date (Electronic): 28 November 2008

Volume: 17

Issue: 3

Pages: 224-234

Affiliations

Kraftsow Renal Section and Womens’ League for Medical Research Laboratories, Department of Medicine, Albert Einstein Medical Center, Philadelphia, Pa.

Article

Publisher ID: 180726 Other ID: Nephron 1976;17:224–234

DOI: 10.1159/000180726

PubMed ID: 940628

SO-VID: b9a408cc-b3a0-47e7-a237-82cbc23f856a

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 23 June 1975

Date accepted : 25 August 1975

Page count

Pages: 11

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