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      Ultrastructural localization of the herpes simplex virus major DNA-binding protein in the nucleus of infected cells.

      The Journal of General Virology

      Cell Nucleus, analysis, DNA, Viral, DNA-Binding Proteins, ultrastructure, Fluorescent Antibody Technique, Histocytochemistry, Immunoenzyme Techniques, Microscopy, Electron, Simplexvirus

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          Abstract

          Using immunocytochemical procedures in conjunction with electron microscopy we have examined the distribution of the major DNA-binding protein (DBP) of herpes simplex virus (HSV) in infected nuclei. In embedded specimens, DBP was preferentially associated with fibrillar material of electron-translucent viral inclusions, and to a lesser extent with peripheral (marginated) host chromatin. The latter association was sensitive to a non-ionic detergent ('Photo flo'). In chromatin spread by the Miller technique, DBP was found to be a component of the 10 nm 'thick filaments' previously described in HSV infection.

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