For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
21
views
16
references
 Top references
cited by
7
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      270
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      IL-15 increases the percentage of effector memory CD8 + T cells in rhesus monkeys immunized with HIV vaccine

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Several studies suggested that interleukin (IL)-15 is a promising adjuvant of human immunodeficiency virus (HIV) vaccine via promoting cellular immunity. Here we evaluated the effect of IL-15 plasmid on HIV specific immune response, especially cellular immunity, in 8 rhesus monkeys. These monkeys were immunized three times with HIV DNA vaccine with or without IL-15 plasmid, and boosted with recombinant Tiantan strain vaccinia virus-based HIV vaccine (rTV) 22 weeks after the first immunization. As the results, the percentages of effector CD8 + memory T cells in the peripheral blood were significantly higher in the group with IL-15 co-immunization (Group T) than those in the group with HIV vaccine alone (Group C) at almost all the time points, while no significant difference in HIV specific CD8 + T cells response was found between Group T and Group C throughout the experiment. The titers of anti-HIV antibodies were higher in Group T than those in Group C after rTV boosting as well. These findings in rhesus monkeys suggest that IL-15 may be used as a cytokine adjuvant for HIV vaccine.

          Related collections

          Most cited references16

          • Record: found
          • Abstract: found
          • Article: not found

          Cytokine control of memory T-cell development and survival.

          Kimberly Schluns, Leo Lefrancois (2003)
          Evidence has accumulated that cytokines have a fundamental role in the differentiation of memory T cells. Here, we follow the CD8+ T cell from initial activation to memory-cell generation, indicating the checkpoints at which cytokines determine the fate of the T cell. Members of the common cytokine-receptor gamma-chain (gammac)-cytokine family--in particular, interleukin-7 (IL-7) and IL-15--act at each stage of the immune response to promote proliferation and survival. In this manner, a stable and protective, long-lived memory CD8+ T-cell pool can be propagated and maintained.
          Article 0 comments Cited 170 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis.

            Averil Ma, Rima Koka, Patrick R. Burkett (2006)
            IL-2, IL-15, and IL-7 are cytokines that are critical for regulating lymphoid homeostasis. These cytokines stimulate similar responses from lymphocytes in vitro, but play markedly divergent roles in lymphoid biology in vivo. Their distinct physiological functions can be ascribed to distinct signaling pathways initiated by proprietary cytokine receptor chains, differential expression patterns of the cytokines or their receptor chains, and/or signals occurring in distinct physiological contexts. Recently, the discovery of a novel mechanism of cytokine signaling, trans-presentation, has provided further insights into the different ways these cytokines function. Trans-presentation also raises several novel cell biological and cellular implications concerning how cytokines support lymphoid homeostasis.
            Article 0 comments Cited 166 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Safety and immunologic effects of IL-15 administration in nonhuman primates.

              James C. Elliott, C. Jensen, Robert Hackman … (2009)
              The administration of cytokines that modulate endogenous or transferred T-cell immunity could improve current approaches to clinical immunotherapy. Interleukin-2 (IL-2) is used most commonly for this purpose, but causes systemic toxicity and preferentially drives the expansion of CD4(+)CD25(+)Foxp3(+) regulatory T cells, which can inhibit antitumor immunity. IL-15 belongs to the gamma(c) cytokine family and possesses similar properties to IL-2, including the ability to induce T-cell proliferation. Whereas IL-2 promotes apoptosis and limits the survival of CD8(+) memory T cells, IL-15 is required for the establishment and maintenance of CD8(+) T-cell memory. However, limited data are available to guide the clinical use of IL-15. Here, we demonstrate in nonhuman primates that IL-15 administration expands memory CD8(+) and CD4(+) T cells, and natural killer (NK) cells in the peripheral blood, with minimal increases in CD4(+)CD25(+)Foxp3(+) regulatory T cells. Daily administration of IL-15 resulted in persistently elevated plasma IL-15 levels and transient toxicity. Intermittent administration of IL-15 allowed clearance of IL-15 between doses and was safe for more than 3 weeks. These findings demonstrate that IL-15 has profound immunomodulatory properties distinct from those described for IL-2, and suggest that intermittent administration of IL-15 should be considered in clinical studies.
              Article 0 comments Cited 77 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                :
                Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing 100005, China
                :
                National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China
                :
                National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China
                :
                Division of Virology and Immunology, National Center for AIDS/STD Control and prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China
                :
                Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, National Key Laboratory of Medical Molecular Biology, Beijing 100005, China
                :
                National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China
                :
                Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, National Key Laboratory of Medical Molecular Biology, Beijing 100005, China
                Journal
                Journal ID (nlm-journal-id): 101242872
                Journal ID (pubmed-jr-id): 32590
                Journal ID (nlm-ta): Cell Mol Immunol
                Title: Cellular & Molecular Immunology
                ISSN (Print): 1672-7681
                ISSN (Electronic): 2042-0226
                Publication date Nihms-submitted: 15 July 2010
                Publication date (Electronic): 27 September 2010
                Publication date (Print): November 2010
                Publication date PMC-release: 18 June 2012
                Volume: 7
                Issue: 6
                Pages: 491-494
                Affiliations
                Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing 100005, China
                National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China
                National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China
                Division of Virology and Immunology, National Center for AIDS/STD Control and prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China
                Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, National Key Laboratory of Medical Molecular Biology, Beijing 100005, China
                National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China
                Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, National Key Laboratory of Medical Molecular Biology, Beijing 100005, China
                Author notes
                Corresponding author: Wei He, Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, National Key Laboratory of Medical Molecular Biology, 5 Dong Dan San Tiao, Beijing 100005, China, Tel: 86-10-65136981; Fax: 86-10-65105909; heweiimu@ 123456public.bta.net.cn
                Article
                Manuscript ID: NIHMS220070
                DOI: 10.1038/cmi.2010.44
                PMC ID: 3376407
                PubMed ID: 20871629
                SO-VID: b9b3f48e-7018-406f-86b9-c39482eed34f
                History
                Funding
                Funded by: National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID
                Award ID: U19 AI051915-05 ||AI
                Categories
                Subject: Article

                ScienceOpen disciplines: Immunology
                Keywords: adjuvant,il-15,effector memory cd8+ t cell,hiv vaccine
                Data availability:
                ScienceOpen disciplines: Immunology
                Keywords: adjuvant, il-15, effector memory cd8+ t cell, hiv vaccine

                Comments

                Comment on this article

                scite_

                Similar content270

                See all similar

                Cited by7

                See all cited by

                Most referenced authors468

                See all reference authors