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      The Involvement of Oxidative Stress in the Progression of Renal Injury

      ,

      Blood Purification

      S. Karger AG

      Oxidative stress, Kidney, Growth, Progression, Chronic renal injury

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          Abstract

          That reactive oxygen species are involved in progressive renal injury is supported by several lines of evidence: increased generation of oxidants occurs in chronic renal injury; various antioxidant strategies exert beneficial effects in models of chronic renal injury; and, oxidative stress can induce changes in the otherwise unmanipulated kidney that resemble those seen in chronic renal disease. Oxidants may contribute to progressive renal disease by virtue of their renal haemodynamic actions, by impairing glomerular permselective properties, by inducing inordinate or aberrant growth responses, by inducing loss of cellular phenotype and apoptosis, and finally, by promoting acute and chronic inflammatory responses. Certain adhesion molecules and proinflammatory mediators, and the transcription factor NFκB, can be upregulated by oxidants. Oxidants can also induce the fibrogenic cytokine, TGFβ1, one that is widely incriminated in progressive renal injury. Reduction in renal oxidative stress by dietary or pharmacologic approaches provides an appealing target for therapies directed towards the retardation of progressive renal injury.

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          Most cited references 5

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          Transforming growth factor beta in tissue fibrosis.

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            Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

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                Author and article information

                Journal
                BPU
                Blood Purif
                10.1159/issn.0253-5068
                Blood Purification
                S. Karger AG
                978-3-8055-6918-7
                978-3-318-00464-9
                0253-5068
                1421-9735
                1999
                1999
                12 August 1999
                : 17
                : 2-3
                : 58-65
                Affiliations
                Nephrology Research Unit, Mayo Clinic/Foundation, Rochester, Minn., USA
                Article
                14377 Blood Purif 1999;17:58–65
                10.1159/000014377
                10449863
                © 1999 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 2, Tables: 1, References: 48, Pages: 8
                Product
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/14377
                Categories
                Paper

                Cardiovascular Medicine, Nephrology

                Chronic renal injury, Progression, Growth, Kidney, Oxidative stress

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