0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Response of Mouse Lens to Central Needle Injury

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          We examined the difference in response to different degrees of injury in the mouse lens. The anterior side of the lens was pricked through the cornea by a microsyringe with a 31-gauge needle or an ordinary needle. The location of the needle tip was mostly marked with Evans’ blue (EB) stain. At least three types of responses were recognizable. The first was a recovery type in which the wound was healed by an epithelial reaction. EB was localized at the superficial zone of the anterior cortex. The second was a type in which the change within the lens was stationary after forming a spherical body with a slightly smaller diameter than that of the entire lens. EB was observed in the intermediate zone of the anterior cortex. The third was a rapid progressive type of cataract which caused lens opacity within 3 days. The trace of the needle tip was observed around the perinuclear zone. These results suggest that the cortex of the mouse lens consists of three zones which may be functionally different around the lens nucleus: superficial, intermediate and perinuclear zones.

          Related collections

          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1994
          1994
          11 December 2009
          : 26
          : 3
          : 181-188
          Affiliations
          Department of Ophthalmology, School of Medicine, Kitasato University, Kanagawa, Japan
          Article
          267410 Ophthalmic Res 1994;26:181–188
          10.1159/000267410
          8090435
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Original Paper

          Comments

          Comment on this article