The burden and management of cytochrome P450 2D6 (CYP2D6)-mediated drug-drug interaction (DDI): co-medication of metoprolol and paroxetine or fluoxetine in the elderly.

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Abstract

Metoprolol and paroxetine/fluoxetine are inevitably co-prescribed because cardiovascular disorders and depression often coexist in the elderly. This leads to CYP2D6-mediated drug-drug interactions (DDI). Because systematic evaluations are lacking, we assessed the burden of metoprolol-paroxetine/fluoxetine interaction in the elderly and how these interactions are managed in Dutch community pharmacies.

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Journal

Journal ID (iso-abbrev): Pharmacoepidemiol Drug Saf

Title: Pharmacoepidemiology and drug safety

Publisher: Wiley

ISSN (Electronic): 1099-1557

ISSN (Print): 1053-8569

Publication date (Electronic): Jul 2017

Volume: 26

Issue: 7

Affiliations

[1 ] University of Groningen, Groningen Research Institute of Pharmacy, Department of PharmacoTherapy, -Epidemiology & -Economics, Groningen, The Netherlands.

[2 ] Hasanuddin University, Faculty of Pharmacy, Makassar, Indonesia.

[3 ] Health Base Foundation, Department of Clinical Decision Support, Houten, The Netherlands.

[4 ] University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, The Netherlands.

Article

DOI: 10.1002/pds.4200

PubMed ID: 28345306

SO-VID: ba05348c-56eb-4171-ab5d-ec1c5b463d95

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Keywords: CYP2D6,beta-blockers,cytochrome P450 (CYP)-based drug-drug interactions (DDI),metoprolol,paroxetine/fluoxetine,pharmacoepidemiology,antidepressants

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Keywords: CYP2D6, beta-blockers, cytochrome P450 (CYP)-based drug-drug interactions (DDI), metoprolol, paroxetine/fluoxetine, pharmacoepidemiology, antidepressants

The burden and management of cytochrome P450 2D6 (CYP2D6)-mediated drug-drug interaction (DDI): co-medication of metoprolol and paroxetine or fluoxetine in the elderly.

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