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      Antimicrobial activity of 2.5% sodium hypochlorite and 0.2% chlorhexidine gluconate separately and combined, as endodontic irrigants.

      1 ,
      Journal of endodontics
      Elsevier BV

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          Abstract

          Sodium hypochlorite irrigant is known to be toxic to periapical tissues. Chlorhexidine gluconate, a safer and effective antimicrobial irrigant, is not known to dissolve pulpal tissues. To obtain their optimal properties, their combined action within the root canal was evaluated. Ten single rooted nonvital anterior teeth were irrigated using either 2.5% sodium hypochlorite alone, 0.2% chlorhexidine gluconate alone, 2.5% sodium hypochlorite and 0.2% chlorhexidine gluconate combined within the root canal, or 0.9% saline, respectively. Microbiological samples for culture and Gram's staining were taken before and proceeding irrigation. This study indicates that the use of sodium hypochlorite and chlorhexidine gluconate combined within the root canal resulted in the greatest percentage reduction of postirrigant positive cultures. This may be due to formation of "chlorhexidine chloride," which increases the ionizing capacity of the chlorhexidine molecule. This reduction was significant compared to use of sodium hypochlorite alone but not significant compared to use of chlorhexidine gluconate alone.

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          Author and article information

          Journal
          J Endod
          Journal of endodontics
          Elsevier BV
          0099-2399
          0099-2399
          Jul 1998
          : 24
          : 7
          Affiliations
          [1 ] Department of Conservative Dentistry and Endodontics, College of Dental Surgery, Mangalore, India.
          Article
          S0099-2399(98)80049-6
          10.1016/S0099-2399(98)80049-6
          9693573
          ba14d07c-04a8-4b9d-af71-b58ad5fa4023
          History

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