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      Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation.

      Nature reviews. Immunology
      Animals, CARD Signaling Adaptor Proteins, immunology, Humans, Infection, Inflammation, Mice, Models, Immunological

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          Abstract

          The NOD-like receptors have important roles in innate immunity as intracellular sensors of microbial components and cell injury. It has been proposed that these cytosolic proteins regulate the cysteine protease caspase-1 within a multiprotein complex known as the 'inflammasome'. Activation of caspase-1 leads to the cleavage and activation of pro-inflammatory cytokines such as interleukin-1beta (IL-1beta) and IL-18, as well as host-cell death. The analysis of mice that are deficient in various inflammasome components has revealed that the inflammasome is a dynamic entity that is assembled from different adaptors in a stimulus-dependent manner. Here we review recent work on the activation of the inflammasome in response to various bacterial pathogens and tissue damage.

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          Author and article information

          Journal
          17186029
          10.1038/nri1997

          Chemistry
          Animals,CARD Signaling Adaptor Proteins,immunology,Humans,Infection,Inflammation,Mice,Models, Immunological

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