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      Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.

      Nature
      Amino Acid Sequence, Animals, Base Sequence, Chromosome Mapping, DNA-Binding Proteins, genetics, Dwarfism, Pituitary, Gene Expression, Genes, Homeobox, Growth Hormone, Mice, Mice, Inbred C3H, Mice, Inbred Strains, Molecular Sequence Data, Mutation, Nucleic Acid Hybridization, Phenotype, Pituitary Gland, Anterior, cytology, growth & development, metabolism, Polymorphism, Restriction Fragment Length, Prolactin, Restriction Mapping, Transcription Factor Pit-1, Transcription Factors

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          Abstract

          Mutations at the mouse dwarf locus (dw) interrupt the normal development of the anterior pituitary gland, resulting in the loss of expression of growth hormone, prolactin and thyroid-stimulating hormone, and hypoplasia of their respective cell types. Disruptions in the gene encoding the POU-domain transcription factor, Pit-1, occur in both characterized alleles of the dwarf locus. The data indicate that Pit-1 is necessary for the specification of the phenotype of three cell types in the anterior pituitary, and directly link a transcription factor to commitment and progression events in mammalian organogenesis.

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