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      Investigate the relation of procalcitonin and prognosis in severe septic patients in SICU

      Intensive Care Medicine Experimental
      Springer

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          Abstract

          Introduction In recent years, procalcitonin(PCT) ,as a new biological marker of systemic bacterial infection, is closely related to the prognosis of sepsis and its role in sepsis is becoming more and more attention. Objectives To investigate the procalcitonin in relations with APCHE II score and prognosis in severe septic patients in SICU. Methods To Collect 64 cases with severe sepsis hospitalized in SICU of the First Affiliated hospital of Sun Yat-sen University from December 2012 to December 2013, retrospectively. Monitored the dynamic changes of serum PCT,C-reactive protein(CRP), vital signs, blood routine test on the 1st, 3rd and 7th day after admission to SICU, the Acute Physiology and Chronic Health Evaluation II (APACHE II) scores were recorded. Compared the serum PCT, APACHE II, white blood cell(WBC), CRP and other inflammation markers between the two groups. The correlation of PCT and APACHE II was evaluated by spearman correlation analysis. The prediction of mortality of the PCT and APACHE II were evaluated by ROC curves. Results There were 33 patients dead and 31 patients survived. The serum PCT level of the patients in the dead group were ((78.49 ± 193.77), (61.55 ± 176.70), (61.68 ± 197.89) ng/ ml) were significantly higher than that in the survived group ((10.70 ± 15.44),(10.60 ± 21.80), (5.67 ± 8.94)ng/ ml) on the 1st, 3th and 7th day(P < 0. 05).The APACHE II score of dead group (21.15 ± 6.93) on 1st day was higher than that of survived group (18.06 ± 5.40) (p < 0.05). There is correlation between PCT and APACHEII .The area under the curve (AUC) was 0.625 (95%CI 0.49-0.76) for PCT, and 0.623 (95%CI 0.49-0.78) for APACHE II. Conclusions Severe septic patient's PCT on 1st day is valuable equal to APACHE II score in prognosis assessment.

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          Effect of severe sepsis on platelet count and their indices.

          Sepsis is a major disease affecting almost all organs and systems.
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            C-reactive protein and bacterial infection in cirrhosis

            In the general population, C-reactive protein (CRP) level increases in the presence of acute or chronic inflammation and infections. In patients with cirrhosis, the basal level is higher than in patients without cirrhosis, due to chronic hepatic and other inflammation, but when infection occurs the more severe the underlying liver dysfunction, the lower the increase in CRP. Therefore, the predictive power of CRP for infection and prognosis is weak in patients with decompensated/advanced cirrhosis and in the intensive care setting. However, higher CRP and also persistently elevated CRP levels can help identify patients with a higher short-term risk of mortality.
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              Biomarkers predicting sepsis in polytrauma patients: Current evidence.

              Major trauma still represents one of the leading causes of death in the first four decades of life. Septic complications represent the predominant causes of late death (45% of overall mortality) in polytrauma patients. The ability of clinicians to early differentiate between systemic inflammatory response syndrome (SIRS) and sepsis is demonstrated to improve clinical outcome and mortality. The identification of an "ideal" biomarker able to early recognize incoming septic complications in trauma patients is still a challenge for researchers.
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                Author and article information

                Journal
                4798415
                10.1186/2197-425X-3-S1-A870
                http://creativecommons.org/licenses/by/4.0

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